{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:46:57Z","timestamp":1786999617679,"version":"build-2736575974"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125101601_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Atrial septal defect is the second most common CHD in adults. This study aimed to evaluate the relationship between age and early postoperative changes in cardiac function\u2014including right ventricular function, tricuspid regurgitation, pulmonary artery pressure, mitral regurgitation, and left ventricular ejection fraction\u2014in adult patients undergoing surgical atrial septal defect repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125101601_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study included 214 patients aged 16\u201365 years who underwent isolated atrial septal defect repair between 2014 and 2024. Patients were divided into five age groups. Echocardiographic parameters were compared at three time points: preoperative, 1-month, and 6-month postoperative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125101601_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the patients, 60.7% were female. A significant postoperative left ventricular ejection fraction decrease was observed only in the 56\u201365 age group. Preoperative tricuspid regurgitation severity and pulmonary artery pressure values increased with age, but both showed significant postoperative improvement across all age groups. Postoperative pulmonary artery pressure reduction was most prominent in the youngest and oldest groups. Mitral regurgitation was mildly increased in all groups, without progression to moderate severity. Tricuspid annular plane systolic excursion values, inversely correlated with age, decreased in younger patients postoperatively but improved in older patients, indicating enhanced right ventricular function after volume unloading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125101601_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Surgical atrial septal defect repair leads to early improvement in several cardiac parameters. However, the benefit is more pronounced in younger patients. These findings support early surgical intervention to preserve right ventricular function and prevent long-term complications, particularly in asymptomatic adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125101601","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T06:03:29Z","timestamp":1755842609000},"page":"1799-1808","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Does age matter? Echocardiographic assessment after isolated atrial septal defect surgery"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2988-4746","authenticated-orcid":false,"given":"Kenan","family":"\u00d6zt\u00fcrker","sequence":"first","affiliation":[{"name":"TC Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Ko\u015fuyolu Y\u00fcksek \u0130htisas E\u011fitim ve Ara\u015ft\u0131rma Hastanesi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Ceyran","sequence":"additional","affiliation":[{"name":"TC Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Ko\u015fuyolu Y\u00fcksek \u0130htisas E\u011fitim ve Ara\u015ft\u0131rma Hastanesi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veysel","family":"Ba\u015far","sequence":"additional","affiliation":[{"name":"TC Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Ko\u015fuyolu Y\u00fcksek \u0130htisas E\u011fitim ve Ara\u015ft\u0131rma Hastanesi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"G\u00fcne\u015f","sequence":"additional","affiliation":[{"name":"TC Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Ko\u015fuyolu Y\u00fcksek \u0130htisas E\u011fitim ve Ara\u015ft\u0131rma Hastanesi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Akbbulut","sequence":"additional","affiliation":[{"name":"TC Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Ko\u015fuyolu Y\u00fcksek \u0130htisas E\u011fitim ve Ara\u015ft\u0131rma Hastanesi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Urve","family":"K\u00f6ksal","sequence":"additional","affiliation":[{"name":"\u00dcmraniye E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"S1047951125101601_ref6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/aca.ACA_153_17","article-title":"Assessment of ventricular function in patients of atrial septal defect by strain imaging before and after correction","volume":"22","author":"Sandeep Kumar","year":"2019","journal-title":"Ann Card Anaesth"},{"key":"S1047951125101601_ref7","first-page":"132","article-title":"Changes in right ventricular morphology and function after transcatheter closure of atrial septal defect in adults: a cardiac magnetic resonance study","volume":"21","author":"Liang","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"S1047951125101601_ref4","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.athoracsur.2011.05.118","article-title":"Deterioration of mitral valve competence after the repair of atrial septal defect in adults","volume":"92","author":"Jeong-Jun","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"S1047951125101601_ref13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00157.2013"},{"key":"S1047951125101601_ref11","first-page":"507","article-title":"Surgical repair of isolated atrial septal defect in adults: effect of age at operation on outcome","volume":"82","author":"Murphy","year":"1990","journal-title":"Circulation"},{"key":"S1047951125101601_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)01043-2"},{"key":"S1047951125101601_ref8","first-page":"50","article-title":"Mechanisms and management of left ventricular dysfunction in elderly patients","volume":"7","author":"Jani","year":"2022","journal-title":"Geriatrics (Basel)"},{"key":"S1047951125101601_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.01.007"},{"key":"S1047951125101601_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"S1047951125101601_ref5","first-page":"618","volume-title":"Moss and Adams\u2019 Heart disease in infants, children, and adolescents: including the fetus and young adult","author":"Felt","year":"2001"},{"key":"S1047951125101601_ref9","first-page":"640","article-title":"Effects of medical therapy on functional tricuspid regurgitation and right ventricular remodeling","volume":"29","author":"D\u2019Andrea","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"S1047951125101601_ref2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-315287"},{"key":"S1047951125101601_ref1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/aca.ACA_153_17","article-title":"Assessment of Ventricular function in patients of atrial septal defect by strain imaging 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