{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:15:47Z","timestamp":1785420947307,"version":"3.56.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"unspecified","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125101613_as1\">\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Dexmedetomidine is frequently used in paediatric anaesthesia. This includes use in patients with CHD, but detailed analysis of haemodynamics after administration in these patients has not yet been published. We performed a systematic review and meta-analyses examining haemodynamic changes immediately after dexmedetomidine administration in patients with CHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125101613_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a systematic review of PubMed, Embase, and Medline from inception until May 31, 2024. Inclusion criteria were studies that contained children with CHD who received dexmedetomidine for a cardiac procedure and reported at least one haemodynamic variable before and after administration of dexmedetomidine. Exclusion criteria were studies of noncardiac procedures. We performed a meta-analysis on each haemodynamic variable that was reported by at least four studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125101613_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We screened 5383 abstracts. We included 85 studies for review, and 16 studies were accepted for four meta-analyses (heart rate, 16 studies,\n                      <jats:italic>n<\/jats:italic>\n                      = 408; systolic blood pressure, 11 studies,\n                      <jats:italic>n<\/jats:italic>\n                      = 280; diastolic blood pressure, 10 studies,\n                      <jats:italic>n<\/jats:italic>\n                      = 276; mean arterial pressure, 5 studies,\n                      <jats:italic>n<\/jats:italic>\n                      = 130). Analysis of heart rate, systolic blood pressure, and diastolic blood pressure showed a statistically significant reduction (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), while there was no significant change in mean arterial pressure. The clinical difference was minimal with a decrease in heart rate of 11.3 beats per minute, and a decrease in systolic blood pressure\/diastolic blood pressure of 5.9 and 6.2 mmHg, respectively. Heterogeneity was high in all analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125101613_as4\">\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Dexmedetomidine is associated with small changes in heart rate, systolic blood pressure, and diastolic blood pressure in children with CHD. Further study is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125101613","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T08:54:37Z","timestamp":1763974477000},"page":"2321-2326","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Dexmedetomidine administration is associated with small haemodynamic changes in children undergoing cardiac procedures: a systematic review and meta-analysis"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7541-2453","authenticated-orcid":false,"given":"Noa","family":"Rose","sequence":"first","affiliation":[{"name":"Tel Aviv University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed Al","family":"Hassanieh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/044ntvm43","id-type":"ROR","asserted-by":"publisher"}],"name":"Montefiore Medical Center"},{"id":[{"id":"https:\/\/ror.org\/05cf8a891","id-type":"ROR","asserted-by":"publisher"}],"name":"Albert Einstein College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Jackson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/044ntvm43","id-type":"ROR","asserted-by":"publisher"}],"name":"Montefiore Medical Center"},{"id":[{"id":"https:\/\/ror.org\/05cf8a891","id-type":"ROR","asserted-by":"publisher"}],"name":"Albert Einstein College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"S1047951125101613_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0568-1"},{"key":"S1047951125101613_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12228"},{"key":"S1047951125101613_ref25","first-page":"1","article-title":"Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: a randomized trial","volume":"6","author":"Totonchi","year":"2017","journal-title":"Res Cardiovasc Med."},{"key":"S1047951125101613_ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1597696"},{"key":"S1047951125101613_ref4","first-page":"00147","article-title":"Association of dexmedetomidine use with haemodynamics, postoperative recovery, and cost in paediatric anaesthesia: a hospital registry study","volume":"S0007","author":"Azimaraghi","year":"2024","journal-title":"Br J Anaesth"},{"key":"S1047951125101613_ref17","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181f7e2ab"},{"key":"S1047951125101613_ref18","doi-asserted-by":"publisher","DOI":"10.4103\/aca.ACA_115_19"},{"key":"S1047951125101613_ref19","first-page":"869049","article-title":"Effects of dexmedetomidine-fentanyl infusion on blood pressure and heart rate during cardiac surgery in children","volume":"2010","author":"Klamt","year":"2010","journal-title":"Anesthesiol Res Pract"},{"key":"S1047951125101613_ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s42077-019-0022-1"},{"key":"S1047951125101613_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2022.110908"},{"key":"S1047951125101613_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-1782-z"},{"key":"S1047951125101613_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12292"},{"key":"S1047951125101613_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.04.099"},{"key":"S1047951125101613_ref2","first-page":"833","article-title":"Dexmedetomidine as an adjuvant to bupivacaine in Caudal Analgesia in children undergoing infra-umbilical surgery","volume":"32","author":"Haque","year":"2023","journal-title":"Mymensingh Med 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Anestesiol"},{"key":"S1047951125101613_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2010.03285.x"},{"key":"S1047951125101613_ref23","doi-asserted-by":"publisher","DOI":"10.4103\/aca.ACA_23_17"},{"key":"S1047951125101613_ref24","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2005.07.018"},{"key":"S1047951125101613_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.01.071"},{"key":"S1047951125101613_ref7","first-page":"409","article-title":"[Effect of dexmedetomidine on hemodynamics in pediatric patients following cardiac surgery]","volume":"56","author":"Tobise","year":"2007","journal-title":"Masui"},{"key":"S1047951125101613_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.04.010"},{"key":"S1047951125101613_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2021.05.008"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125101613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T03:30:17Z","timestamp":1764559817000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125101613\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1047951125101613"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125101613","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}