{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:55:38Z","timestamp":1789419338141,"version":"build-2803163510"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"unspecified","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951125109268_as1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate whether landiolol combined with amiodarone improves heart rate and rhythm control compared to amiodarone alone in paediatric patients with postoperative junctional ectopic tachycardia after surgery for congenital heart defect.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951125109268_as2\"><jats:title>Methods:<\/jats:title><jats:p>We retrospectively identified 24 cases of junctional ectopic tachycardia among 962 children who underwent surgery for congenital heart defects at the German Paediatric Heart Centre between January 2022 and June 2024. Patients received either amiodarone monotherapy or a combination of landiolol and amiodarone. Time to heart rate control and rhythm normalisation, haemodynamic stability, and adverse events were assessed.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951125109268_as3\"><jats:title>Results:<\/jats:title><jats:p>Patients who received amiodarone and landiolol achieved faster heart rate control than patients who received amiodarone alone (median 6.7 vs. 14.7 h, <jats:italic>p<\/jats:italic> = 0.02, Cohen\u2019s <jats:italic>d<\/jats:italic> = 1.05; large effect). Among patients who received landiolol first, control was reached even earlier (2.4 vs. 8 h, <jats:italic>p<\/jats:italic> = 0.05, Cohen\u2019s <jats:italic>d<\/jats:italic> = 1.49; very large effect). A significant heart rate reduction occurred within 40\u2013120 min after landiolol initiation (mean difference: \u221223.7 bpm, 95% CI: \u221245.4 to \u22121.9, <jats:italic>p<\/jats:italic> = 0.04, <jats:italic>r<\/jats:italic> = 0.45; medium effect), while no significant effect was observed in patients who received amiodarone alone. Haemodynamic parameters remained stable, although hypotension requiring discontinuation occurred in 11.1% of Landiolol-treated patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951125109268_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>In this retrospective analysis, combined landiolol and amiodarone therapy demonstrated a shorter time to heart rate control compared to amiodarone alone, especially when landiolol was initiated first. These findings require confirmation in prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951125109268","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T07:40:58Z","timestamp":1757403658000},"page":"1906-1912","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["An exploratory study of landiolol plus amiodarone versus amiodarone monotherapy in paediatric junctional ectopic tachycardia after surgery"],"prefix":"10.1017","volume":"35","author":[{"given":"Luz","family":"Sandoval","sequence":"first","affiliation":[{"name":"University of Bonn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Arenz","sequence":"additional","affiliation":[{"name":"University of Bonn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hamann","sequence":"additional","affiliation":[{"name":"University of Bonn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-320X","authenticated-orcid":false,"given":"Sven","family":"Chlench","sequence":"additional","affiliation":[{"name":"University of Bonn"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"S1047951125109268_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut044"},{"key":"S1047951125109268_ref27","doi-asserted-by":"publisher","DOI":"10.1177\/2150135117732544"},{"key":"S1047951125109268_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-015-2119-4"},{"key":"S1047951125109268_ref14","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.athoracsur.2013.01.057","article-title":"Effects of landiolol hydrochloride on intractable tachyarrhythmia after pediatric cardiac surgery","volume":"95","author":"Tokunaga","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"S1047951125109268_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12410"},{"key":"S1047951125109268_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2012.11.007"},{"key":"S1047951125109268_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.04.002"},{"key":"S1047951125109268_ref9","doi-asserted-by":"publisher","DOI":"10.4103\/apc.apc_35_21"},{"key":"S1047951125109268_ref11","doi-asserted-by":"publisher","DOI":"10.2174\/187152910790780032"},{"key":"S1047951125109268_ref22","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-21-0967"},{"key":"S1047951125109268_ref26","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.3.261"},{"key":"S1047951125109268_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001573"},{"key":"S1047951125109268_ref12","volume-title":"StatPearls","author":"Florek","year":"2023"},{"key":"S1047951125109268_ref10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11886-006-0074-2","article-title":"Amiodarone: a multifaceted antiarrhythmic drug","volume":"8","author":"Singh","year":"2006","journal-title":"Curr Cardiol 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as a first-line therapy for postoperative junctional ectopic tachycardia","volume":"88","author":"Kovacikova","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"S1047951125109268_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-019-02090-7"},{"key":"S1047951125109268_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/sux037"},{"key":"S1047951125109268_ref30","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-024-01418-8"},{"key":"S1047951125109268_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2022.07.013"},{"key":"S1047951125109268_ref13","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.40.1462"},{"key":"S1047951125109268_ref20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.00097.x"}],"container-title":["Cardiology in the 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}