{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:18:05Z","timestamp":1768879085406,"version":"3.49.0"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"unspecified","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CHD has been historically associated with the development of cerebral abscess. This retrospective cohort study examines the association of CHD with the occurrence of cerebral abscess in an inpatient paediatric population. We analysed data from the Pediatric Health Information System database, an administrative database that captures data from participating children\u2019s hospitals in the United States. We included all patients admitted to participating paediatric ICUs between 2016 and 2021 for a total of 426,029 admissions. Including all admissions, 1,387 (0.3%) patients experienced a cerebral abscess, and of 80,927 (19%) patients with CHD, only 88 (0.1%) experienced a cerebral abscess (odds ratio 0.29, 0.23\u20130.36). Patients with seizures, cerebral oedema, stroke, shock, surgical intervention, and older age were associated with increased risk of development of a cerebral abscess. Interestingly, the development of a cerebral abscess was not associated with an increased risk of mortality (<jats:italic>p<\/jats:italic> = 0.937). When compared to patients without CHD admitted to the paediatric ICU, those with CHD appear less likely to develop a cerebral abscess. This study reiterates that cerebral abscess is a rare occurrence and does not demonstrate any significant association with CHD in a contemporary, inpatient population in the United States.<\/jats:p>","DOI":"10.1017\/s1047951125109293","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T07:50:01Z","timestamp":1758527401000},"page":"1913-1916","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Association between CHD and cerebral abscess: insights from a national database"],"prefix":"10.1017","volume":"35","author":[{"given":"Keats","family":"Ewing","sequence":"first","affiliation":[{"name":"Ann and Robert H Lurie Children\u2019s Hospital of Chicago, Northwestern University Feinberg School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-2835","authenticated-orcid":false,"given":"Rohit Seath","family":"Loomba","sequence":"additional","affiliation":[{"name":"Ann and Robert H Lurie Children\u2019s Hospital of Chicago, Northwestern University Feinberg School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-5775","authenticated-orcid":false,"given":"Saul","family":"Flores","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital\/Baylor School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8993-5192","authenticated-orcid":false,"given":"Enrique G.","family":"Villarreal","sequence":"additional","affiliation":[{"name":"Escuela de Medicina y Ciencias de la Salud"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-2876","authenticated-orcid":false,"given":"Juan S.","family":"Farias","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-5115","authenticated-orcid":false,"given":"Matthew Taylor","family":"Coghill","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"S1047951125109293_ref9","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1651-2227.2010.01780.x","article-title":"Brain abscess in children - epidemiology, predisposing factors and management in the modern medicine era","volume":"99","author":"Shachor-Meyouhas","year":"2010","journal-title":"Acta Paediatr"},{"key":"S1047951125109293_ref12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.wneu.2017.07.144","article-title":"Cardiogenic brain abscess in children: a case series-based review","volume":"107","author":"Udayakumaran","year":"2017","journal-title":"World Neurosurg"},{"key":"S1047951125109293_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268817001583"},{"key":"S1047951125109293_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182748d6e"},{"key":"S1047951125109293_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-019-04182-4"},{"key":"S1047951125109293_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304791"},{"key":"S1047951125109293_ref2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.6.1765"},{"key":"S1047951125109293_ref4","first-page":"CD004469","article-title":"Antibiotics for brain abscesses in people with cyanotic congenital heart disease","volume":"3","author":"Lumbiganon","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"S1047951125109293_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(74)90099-X"},{"key":"S1047951125109293_ref3","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.32.667"},{"key":"S1047951125109293_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S104795112100281X"},{"key":"S1047951125109293_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.09.186"},{"key":"S1047951125109293_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/21501351211032919"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125109293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T11:56:31Z","timestamp":1759492591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125109293\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1047951125109293"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125109293","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}