{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:53:34Z","timestamp":1791345214852,"version":"4.3.1"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"unspecified","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The anomalous origin of the right pulmonary artery from the ascending aorta is a rare congenital anomaly usually diagnosed in infancy. When diagnosed later during adolescence, it presents diagnostic and treatment challenges, especially in determining whether pulmonary vascular disease can be reversed. We report the case of an 11-year-old girl who experienced increasing fatigue and was diagnosed with anomalous origin of the right pulmonary artery from the ascending aorta through echocardiography, CT angiography, and cardiac catheterisation. Segmental pulmonary hypertension was noted, but the operability was uncertain. A new non-invasive test combining 2D phase-contrast cardiac MRI with inhaled iloprost was performed. Flow measurements revealed a 42% rise in right pulmonary artery flow, indicating preserved vasoreactivity. Lung biopsy confirmed pulmonary vascular changes consistent with Heath\u2013Edwards Stage II\u2013III. Based on these findings, surgical reimplantation of the anomalous artery into the main pulmonary artery was performed. The postoperative recovery after surgery was uneventful, and follow-up catheterisation demonstrated normalised haemodynamics without residual stenosis. This case highlights the potential value of cardiac MRI\u2013based vasoreactivity testing with inhaled iloprost as an additional tool alongside standard diagnostics for evaluating operability in late-presenting anomalous origin of the right pulmonary artery from the ascending aorta. Combining imaging, histopathology, and haemodynamic data allowed a personalised and safe surgical approach.<\/jats:p>","DOI":"10.1017\/s1047951125109670","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:30:03Z","timestamp":1762860603000},"page":"2353-2356","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Inhaled iloprost and 2D phase-contrast cardiac MRI in pulmonary vascular reversibility: an adolescent case of anomalous right pulmonary artery from the ascending aorta"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6332-5302","authenticated-orcid":false,"given":"Mete Han","family":"K\u0131z\u0131lkaya","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00jzwgz36","id-type":"ROR","asserted-by":"publisher"}],"name":"Koc University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Salih","family":"Bilal","sequence":"additional","affiliation":[{"name":"Medicana Health Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terman","family":"Gumus","sequence":"additional","affiliation":[{"name":"Koc University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpay","family":"\u00c7eliker","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00jzwgz36","id-type":"ROR","asserted-by":"publisher"}],"name":"Koc University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"S1047951125109670_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.07.023"},{"key":"S1047951125109670_ref10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1240746"},{"key":"S1047951125109670_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs110"},{"key":"S1047951125109670_ref3","first-page":"1","article-title":"Abnormal origin of the right pulmonary artery from ascending aorta (Hemitruncus arteriosus)","volume":"2","author":"Haywood","year":"2014","journal-title":"J Investig Med High Impact Case Rep"},{"key":"S1047951125109670_ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.607104"},{"key":"S1047951125109670_ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000126494.66859.A2"},{"key":"S1047951125109670_ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951120001729"},{"key":"S1047951125109670_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2018.09.002"},{"key":"S1047951125109670_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.14322"},{"key":"S1047951125109670_ref5","doi-asserted-by":"publisher","DOI":"10.4103\/apc.apc_98_22"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125109670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T03:30:15Z","timestamp":1764559815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125109670\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1047951125109670"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125109670","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}