{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:39:59Z","timestamp":1785436799923,"version":"3.56.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,11]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n The timing for intervention in patients with significant chronic aortic regurgitation is based on adult guidelines and criteria which may not apply to children. There is limited data on the use of cardiac MRI parameters to guide surgical decision-making in paediatrics. We examined associations between MRI quantification of aortic regurgitation and left ventricular volumetric function and the need for surgical intervention.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Forty children and young adults with aortic regurgitation who had undergone cardiac MRI were divided into two groups based on aortic valve surgery (\n n<\/jats:italic>\n = 20) or no surgery (\n n<\/jats:italic>\n = 20). Ventricular volumetric functional parameters and aortic regurgitant volume and fraction were collected. Differences in MRI parameters between the groups were compared using unpaired t-tests. Receiver operating characteristic analysis identified MRI cut-off values with discriminatory ability towards primary end point of surgery (area under the curve > 0.7).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Patients who underwent surgery had significantly larger ventricular volumes and aortic regurgitant fraction than those without surgery. Aortic regurgitant fraction and volume had the highest discriminatory power (0.93 and 0.92, respectively) between the two groups, followed by indexed left ventricular volumes (end-diastolic volume 0.85 and end-systolic volume 0.89).<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Current guidelines for surgical intervention in children with chronic aortic regurgitation are limited. Our findings suggest potential MRI-based threshold values that may aid in surgical decision-making and highlight the need future research for aortic valve surgery in children with chronic aortic regurgitation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/s1047951125109839","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T05:12:22Z","timestamp":1760677942000},"page":"2306-2310","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac magnetic resonance parameters associated with surgery in a paediatric and young adult population with chronic aortic regurgitation"],"prefix":"10.1017","volume":"35","author":[{"given":"Amol","family":"Moray","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0160cpw27","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Pagano","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0160cpw27","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Noga","sequence":"additional","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging, University of Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-5375","authenticated-orcid":false,"given":"Edythe B.","family":"Tham","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0160cpw27","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"S1047951125109839_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0646-z"},{"key":"S1047951125109839_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12009"},{"key":"S1047951125109839_ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-022-00895-2"},{"key":"S1047951125109839_ref7","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000029"},{"key":"S1047951125109839_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-024-03073-3"},{"key":"S1047951125109839_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.03.411"},{"key":"S1047951125109839_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00329-X"},{"key":"S1047951125109839_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.12.017"},{"key":"S1047951125109839_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.024"},{"key":"S1047951125109839_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.03.001"},{"key":"S1047951125109839_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jet129"},{"key":"S1047951125109839_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.08.042"},{"key":"S1047951125109839_ref3","first-page":"e35","article-title":"ACC\/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"S1047951125109839_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.11.014"},{"key":"S1047951125109839_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.12.021"},{"key":"S1047951125109839_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.05.006"},{"key":"S1047951125109839_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.083600"},{"key":"S1047951125109839_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0529-8"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125109839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T03:30:14Z","timestamp":1764559814000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125109839\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1047951125109839"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125109839","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}