{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:32:30Z","timestamp":1785418350002,"version":"3.56.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"unspecified","delay-in-days":8,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125110238_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Infants with CHD who undergo cardiopulmonary bypass surgery are at risk of impaired growth and neurodevelopment. However, few studies have thoroughly investigated the risk factors for growth and neurodevelopmental impairments, particularly with respect to the timing of the initial surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110238_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively analysed term singleton infants with CHD who underwent cardiopulmonary bypass surgery at a Japanese tertiary centre between 2015 and 2021. Neurodevelopment was assessed at 18\u201322 months of age using the Kyoto Scale of Psychological Development. We compared outcomes by CHD type (univentricular [UV] vs. biventricular [BV]) and analysed risk factors for growth impairment (weight and height &lt; tenth percentile) and neurodevelopmental impairment (developmental quotient [DQ] &lt; 85), including birth weight, sex, the type of CHD (UV or BV), and timing of the initial cardiopulmonary bypass surgery (&lt;28 days or \u226528 days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110238_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 108 eligible children, 29 had UV physiology and 79 had BV physiology. Both groups showed impaired growth, with significantly lower body weights in the UV group. Neurodevelopmental scores (total DQ) were significantly lower in the UV group. Neurodevelopmental impairment (total DQ &lt; 85) was observed in 44\/108 (40.7%) children, and after adjustment, UV repair was significantly associated with neurodevelopmental impairment (adjusted odds ratio [OR] 3.11, 95% confidence interval [CI] 1.27\u20137.65). Timing of the initial cardiopulmonary bypass surgery was not associated with outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110238_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Infants with CHD in Japan exhibit impaired growth and neurodevelopment at 18\u201322 months following cardiopulmonary bypass surgery, especially those with UV physiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125110238","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:45:55Z","timestamp":1765269955000},"page":"2463-2468","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Growth and neurodevelopment at 18\u201322 months in term infants with CHD undergoing cardiopulmonary bypass surgery: a retrospective cohort study"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4910-9101","authenticated-orcid":false,"given":"Misuzu","family":"Yoshida","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00nx7n658","id-type":"ROR","asserted-by":"publisher"}],"name":"Osaka Women\u2019s and Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3148-9892","authenticated-orcid":false,"given":"Katsuya","family":"Hirata","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00nx7n658","id-type":"ROR","asserted-by":"publisher"}],"name":"Osaka Women\u2019s and Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Nozaki","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00nx7n658","id-type":"ROR","asserted-by":"publisher"}],"name":"Osaka Women\u2019s and Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narutaka","family":"Mochizuki","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00nx7n658","id-type":"ROR","asserted-by":"publisher"}],"name":"Osaka Women\u2019s and Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Hirano","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00nx7n658","id-type":"ROR","asserted-by":"publisher"}],"name":"Osaka Women\u2019s and Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Ishii","sequence":"additional","affiliation":[{"name":"Osaka Women\u2019s and Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Wada","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00nx7n658","id-type":"ROR","asserted-by":"publisher"}],"name":"Osaka Women\u2019s and Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"S1047951125110238_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz009"},{"key":"S1047951125110238_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2017.03.014"},{"key":"S1047951125110238_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-323132"},{"key":"S1047951125110238_ref2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3825"},{"key":"S1047951125110238_ref31","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318265ee8a"},{"key":"S1047951125110238_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200306000-00007"},{"key":"S1047951125110238_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1579-8"},{"key":"S1047951125110238_ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2024-002943"},{"key":"S1047951125110238_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.06.036"},{"key":"S1047951125110238_ref23","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.25.71"},{"key":"S1047951125110238_ref27","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1157"},{"key":"S1047951125110238_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.hco.0000153451.68212.68"},{"key":"S1047951125110238_ref15","first-page":"1017","article-title":"Perioperative risk factors for impaired neuro-development after cardiac surgery in early infancy","volume":"1","author":"Gunn","year":"2016","journal-title":"Arch Dis Child"},{"key":"S1047951125110238_ref9","first-page":"100685","article-title":"Neurodevelopmental outcomes of children with congenital heart disease: a review","volume":"49","author":"Howell","year":"2019","journal-title":"Curr Probl Pediatr Adolesc Health 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Society for the Kyoto Scale of Psychological Development Test. Shinpan K Shiki hattatsu Kensahou 2001 Nenban [The Kyoto Scale of Psychological Development Test 2001]. Nakanishiya Shuppan, Kyoto. 2008. (in Japanese)."},{"key":"S1047951125110238_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.09.025"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125110238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:35:41Z","timestamp":1778758541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125110238\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1047951125110238"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125110238","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}