{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:39:57Z","timestamp":1785436797725,"version":"3.56.0"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"unspecified","delay-in-days":8,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125110251_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aims to evaluate patient outcomes related to mitral valve disease (stenosis, regurgitation, or mixed) who benefited from mitral repair or replacement under one year of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110251_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Monocentric retrospective study including all children with mitral valve repair or replacement under 1 year of age over a period of 22 years (2001\u20132023).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110251_as3\">\n                    <jats:title>The outcomes assessed were:<\/jats:title>\n                    <jats:p>early mortality (at 30 days), late mortality, and need for re-intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110251_as4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 56 patients were identified, with a median age of 147 days and median weight of 5.1 kg. Of these, 39 underwent mitral valve repair and 17 underwent replacement. The median follow-up duration was 2.9 years (interquartile range 0.3\u20138.1). Patients who underwent replacement had longer ICU stays, hospital stays, and assisted ventilation times (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.019), with higher early mortality (12% vs. 0%). Survival was significantly higher in the repair group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.039). Re-intervention was required in 23 patients (41.1%): 16 had replacement, 6 had re-repair, and 2 needed pacemaker implantation. Seven patients (12.5%) needed more than one re-intervention. Re-intervention-free survival rates after repair were 81%, 65%, and 46% at 1, 5, and 10 years, respectively. After replacement, rates were 74% at 1 year and 55% at 5 and 10 years. Conclusion Mitral valve surgery in infants is particularly high risk and is associated with high rate of re-intervention. While mitral repair demonstrates superior outcomes in mortality, it often delays but does not always prevent the need for valve replacement.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125110251","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:45:55Z","timestamp":1765269955000},"page":"2550-2557","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Long-term outcomes of infant mitral valve surgery"],"prefix":"10.1017","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3506-6184","authenticated-orcid":false,"given":"Segolene","family":"Bernheim","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05tr67282","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatric Cardiac Surgery, Pediatric Cardiac Intensive Cardiac Unit, H\u00f4pital Necker-Enfants Malades, Assistance Publique - H\u00f4pitaux de Paris"},{"name":"Universit\u00e9 Paris Cit\u00e9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaux","family":"Pontailler","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05tr67282","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatric Cardiac Surgery, Pediatric Cardiac Intensive Cardiac Unit, H\u00f4pital Necker-Enfants Malades, Assistance Publique - H\u00f4pitaux de Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Moiroux-Sahraoui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, H\u00f4pital Necker-Enfants Malades, Assistance Publique - H\u00f4pitaux de Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Haydar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05tr67282","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatric Cardiac Surgery, Pediatric Cardiac Intensive Cardiac Unit, H\u00f4pital Necker-Enfants Malades, Assistance Publique - H\u00f4pitaux de Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regis","family":"Gaudin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05tr67282","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatric Cardiac Surgery, Pediatric Cardiac Intensive Cardiac Unit, H\u00f4pital Necker-Enfants Malades, Assistance Publique - H\u00f4pitaux de Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9"},{"name":"Department of Pediatric Cardiology, H\u00f4pital Necker-Enfants Malades, Assistance Publique - H\u00f4pitaux de Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Raisky","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05tr67282","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatric Cardiac Surgery, Pediatric Cardiac Intensive Cardiac Unit, H\u00f4pital Necker-Enfants Malades, Assistance Publique - H\u00f4pitaux de Paris"},{"name":"Universit\u00e9 Paris Cit\u00e9"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"S1047951125110251_ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2020.01.005"},{"key":"S1047951125110251_ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.13580"},{"key":"S1047951125110251_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-019-02262-5"},{"key":"S1047951125110251_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1701-y"},{"key":"S1047951125110251_ref9","first-page":"267","article-title":"Long-term results after mitral valve repair in children","volume":"37","author":"Lee","year":"2010","journal-title":"Eur J Cardio-Thorac"},{"key":"S1047951125110251_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.02.006"},{"key":"S1047951125110251_ref5","first-page":"25","article-title":"Mitral valve replacement in children","volume":"12","author":"Erez","year":"2003","journal-title":"J Heart Valve Dis"},{"key":"S1047951125110251_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.02.057"},{"key":"S1047951125110251_ref12","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivx211"},{"key":"S1047951125110251_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-021-04208-7"},{"key":"S1047951125110251_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.08.085"},{"key":"S1047951125110251_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1062-1458(02)00587-1"},{"key":"S1047951125110251_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.03.026"},{"key":"S1047951125110251_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezac183"},{"key":"S1047951125110251_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.02.057"},{"key":"S1047951125110251_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.11.058"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125110251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:35:42Z","timestamp":1778758542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125110251\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1047951125110251"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125110251","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. 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