{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:12:02Z","timestamp":1785413522837,"version":"3.56.0"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125110457_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Impaired muscle function, aerobic capacity, and fatigue are common in individuals with Fontan circulation. Knowledge regarding the effects of strength training in this population is limited. Therefore, the study aimed to investigate the effects of strength training on dynamic muscle function, aerobic capacity, and fatigue in adults with Fontan circulation compared to matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110457_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this pilot non-randomised controlled trial, nine patients with Fontan circulation (median age 28.9 years [IQR: 23.4\u201335.0], 44.4% women) and nine age- and sex-matched controls completed a 10-week strength training intervention. Dynamic muscle function was assessed through shoulder flexion, heel rise, elbow flexion, and knee extension tests. Aerobic capacity was evaluated using cardiopulmonary exercise testing, and fatigue using the questionnaire\n                      <jats:italic>Multidimensional Fatigue Inventory<\/jats:italic>\n                      . All assessments were conducted\n                      <jats:italic>pre<\/jats:italic>\n                      - and\n                      <jats:italic>post<\/jats:italic>\n                      -intervention. Within-group changes were analysed using the Wilcoxon signed rank test and between-group differences using the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110457_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients showed improvements in all muscle function tests post-intervention (shoulder flexions 39.3% [IQR: 18.9\u201369.7],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008; heel rise 26.7% [IQR:17.5\u201358.1],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008; elbow flexions 57.1% [IQR: 50.0\u2013173.8],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007; knee extensions 66.7% [24.3\u201392.9],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008). The improvements were at comparable levels to controls. Only controls reported reduced fatigue (\u201319.4% [IQR: \u201328.7, \u201310.5],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01), while patients showed no change (\u20135.9% [IQR: \u221225.5, 3.2],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.1). Aerobic capacity remained unchanged. No severe adverse events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110457_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Strength training is safe and improves dynamic muscle function in patients with Fontan circulation, with changes comparable to those of healthy controls. However, the effect of strength training on fatigue and aerobic capacity requires further investigation.<\/jats:p>\n                    <jats:p>\n                      ClinicalTrials.gov, ID: NCT05454254,\n                      <jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:uri>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125110457","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:35:01Z","timestamp":1766392501000},"page":"111-118","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Positive effects of strength training on dynamic muscle function in adults with Fontan circulation: a pilot study"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-9149","authenticated-orcid":false,"given":"Anna","family":"Wikner","sequence":"first","affiliation":[{"name":"Ume\u00e5 University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rinnstr\u00f6m","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05kb8h459","id-type":"ROR","asserted-by":"publisher"}],"name":"Ume\u00e5 University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karna","family":"Johansson","sequence":"additional","affiliation":[{"name":"Ume\u00e5 University"},{"name":"Ume\u00e5 University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frida","family":"Bergman","sequence":"additional","affiliation":[{"name":"Ume\u00e5 University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Ljungberg","sequence":"additional","affiliation":[{"name":"Ume\u00e5 University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Johansson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05kb8h459","id-type":"ROR","asserted-by":"publisher"}],"name":"Ume\u00e5 University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4043-7130","authenticated-orcid":false,"given":"Camilla","family":"Sandberg","sequence":"additional","affiliation":[{"name":"Ume\u00e5 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2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}