{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:01:38Z","timestamp":1785420098780,"version":"3.56.0"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"unspecified","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125110767_as1\">\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>This study investigates the impact of patent ductus arteriosus (PDA) status and treatment response on myocardial adaptation in preterm infants by comparing serial echocardiographic trajectories across three groups: high-risk infants with treatment success, high-risk infants with treatment failure, and low-risk infants not requiring treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110767_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this prospective cohort study, preterm infants born &lt; 29 weeks\u2019 gestation were stratified using the EL-Khuffash PDA Severity Score and subsequent response to medical therapy. Echocardiographic assessments were performed at three timepoints: day 2, 2 weeks, and 36 weeks corrected gestational age. A range of structural and functional parameters was analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110767_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 184 included infants, 58 were high risk with treatment success, 52 were high risk with treatment failure, and 74 were low risk. High-risk infants with treatment failure had persistent myocardial and haemodynamic alterations, including higher left ventricular wall thickness and lower coeliac artery velocities at follow-up. Treatment success was associated with improvements in strain metrics, systemic perfusion, and structural indices. Low-risk infants demonstrated spontaneous PDA closure and overall stable haemodynamics. Distinct differences in the evolution of myocardial trajectories between groups were apparent between day 2 and week 2 echocardiograms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110767_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Serial echocardiographic assessments highlight the dynamic impact of PDA treatment response on myocardial adaptation. Persistent ductal patency despite treatment is associated with sustained structural and functional changes. Early definitive ductal closure may promote haemodynamic stability and mitigate maladaptive remodelling in a subgroup of high-risk infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125110767","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T09:20:45Z","timestamp":1769419245000},"page":"141-149","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Patent ductus arteriosus status and treatment response alters myocardial adaptation in preterm infants"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4126-7003","authenticated-orcid":false,"given":"Rachel","family":"Mullaly","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05t4vgv93","id-type":"ROR","asserted-by":"publisher"}],"name":"The Rotunda Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling","family":"Smith","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05t4vgv93","id-type":"ROR","asserted-by":"publisher"}],"name":"The Rotunda Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orla","family":"Franklin","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Ireland at Crumlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"McCallion","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05t4vgv93","id-type":"ROR","asserted-by":"publisher"}],"name":"The Rotunda Hospital"},{"name":"Royal College of Surgeons in Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afif","family":"EL-Khuffash","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05t4vgv93","id-type":"ROR","asserted-by":"publisher"}],"name":"The Rotunda Hospital"},{"name":"Royal College of Surgeons in Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"S1047951125110767_ref7","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-0663-8"},{"key":"S1047951125110767_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2025-003347"},{"key":"S1047951125110767_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0293-z"},{"key":"S1047951125110767_ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-019-0342-7"},{"key":"S1047951125110767_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2020.105291"},{"key":"S1047951125110767_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12454"},{"key":"S1047951125110767_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025784"},{"key":"S1047951125110767_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2023.11.016"},{"key":"S1047951125110767_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.07.051"},{"key":"S1047951125110767_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.09.028"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125110767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:36:07Z","timestamp":1775795767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125110767\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1047951125110767"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125110767","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}