{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:40:01Z","timestamp":1785426001378,"version":"3.56.0"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"unspecified","delay-in-days":43,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125110792_as1\">\n                    <jats:title>Background &amp; aims:<\/jats:title>\n                    <jats:p>Patients with cyanotic CHD and those with metabolic dysfunction\u2013associated steatotic liver disease are at risk of liver fibrosis. We compared hepatic extracellular volumes and native T1 values to better understand the burden of liver disease in these populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110792_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The sample comprised 136 patients in 5 groups: control (\n                      <jats:italic>n<\/jats:italic>\n                      = 23), metabolic dysfunction\u2013associated steatotic liver disease [mild (F0\u2013F1) and significant (F2\u2013F4) fibrosis;\n                      <jats:italic>n<\/jats:italic>\n                      = 45], repaired tetralogy of Fallot (\n                      <jats:italic>n<\/jats:italic>\n                      = 30), and Fontan circulation (\n                      <jats:italic>n<\/jats:italic>\n                      = 38). Differences were assessed using linear regression models, with adjustment for the body mass index and sex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110792_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The hepatic extracellular volume was significantly larger in the Fontan group (43.96% \u00b1 4.22%) than in the other groups, even with adjustment. Patients with Fallot had significantly larger extracellular volumes (36.77% \u00b1 5.63%) than did controls and mild liver disease (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001 and\n                      <jats:italic>p<\/jats:italic>\n                      = 0.011, respectively), although smaller extracellular volumes than patients with significant liver disease (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.042). These trends were corroborated by native T1 values, which were highest in patients with Fontan (1013.7 \u00b1 86.1 ms), although not significantly different from patients with F2\u2013F4 steatotic liver disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125110792_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The potential burden of CHD-related hepatic injury and steatotic liver disease highlights the importance of early identification. Given the possible additional risk of liver fibrosis in patients with coexisting metabolic dysfunction and CHD, comprehensive clinical management should prioritise regular metabolic risk assessment and the promotion of a healthy lifestyle to reduce the likelihood of liver disease development in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125110792","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:07:19Z","timestamp":1768288039000},"page":"2537-2543","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Assessing liver disease in cyanotic CHD using multiparametric MRI: a call to prevent future burden"],"prefix":"10.1017","volume":"35","author":[{"given":"Mariana","family":"P\u00f3voa-Corr\u00eaa","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mar7r17","id-type":"ROR","asserted-by":"publisher"}],"name":"D\u2019Or Institute for Research and Education (IDOR)"},{"name":"Federal University of Rio de Janeiro (UFRJ)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana M.","family":"Innocenzi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mar7r17","id-type":"ROR","asserted-by":"publisher"}],"name":"D\u2019Or Institute for Research and Education (IDOR)"},{"name":"National Institute of Cardiology (INC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda P.","family":"Fernandes","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mar7r17","id-type":"ROR","asserted-by":"publisher"}],"name":"D\u2019Or Institute for Research and Education (IDOR)"},{"name":"National Institute of Cardiology (INC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Costermani","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mar7r17","id-type":"ROR","asserted-by":"publisher"}],"name":"D\u2019Or Institute for Research and Education (IDOR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos P.","family":"Secco","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mar7r17","id-type":"ROR","asserted-by":"publisher"}],"name":"D\u2019Or Institute for Research and Education (IDOR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via V.O.","family":"Terzi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mar7r17","id-type":"ROR","asserted-by":"publisher"}],"name":"D\u2019Or Institute for Research and Education (IDOR)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana 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