{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:19:41Z","timestamp":1783084781050,"version":"3.54.6"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"unspecified","delay-in-days":3,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951125111104_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aimed to evaluate patients with beta thalassaemia major using the cardiac electrophysiological index of balance, a new electrocardiography parameter, and to predict ventricular arrhythmias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125111104_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this study, 60 beta thalassaemia major and 60 healthy children were included. All patients were evaluated with echocardiography. P-wave dispersion, repolarisation times, repolarisation dispersion times, and cardiac electrophysiological balance index were measured using 12-lead electrocardiography. Heart rate variability parameters were evaluated with a 24-hour Holter electrocardiography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125111104_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Left ventricular functions were similar between the groups. Although repolarisation times (QT, JT, and JTp) were significantly lower in the beta thalassaemia major group, heart rate-corrected repolarisation times were similar. Except for Tpe\/QT, which is one of the repolarisation dispersion parameters, the other parameters were similar. The heart rate-corrected cardiac electrophysiological index of balance ratio was significantly higher in the beta thalassaemia major group. QRS duration and QRS-dispersion duration (QRS-d) were similar between the groups. There was a correlation between blood ferritin levels and LVmass-i, Tpe\/QT, Tpe\/QTc, QTc\/QRS ratio, and QT, JT, and JTp values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125111104_as4\">\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Patients with beta thalassaemia major are at high risk for ventricular arrhythmia due to a high QTc\/QRS ratio, despite normal left ventricular systolic, diastolic, and autonomic function in the early period. We believe that there is a moderate correlation between blood ferritin levels and the QTc\/QRS ratio and that the QTc\/QRS ratio can provide important information for the follow-up and evaluation of patients with beta thalassaemia major.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951125111104_as5\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Despite normal early ventricular function in the beta thalassaemia major group, they were at high risk of ventricular arrhythmias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951125111104","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T04:35:36Z","timestamp":1770179736000},"page":"223-230","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac electrophysiological index of balance evaluation in beta thalassaemia major patients"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3784-7849","authenticated-orcid":false,"given":"Kerem","family":"Erta\u015f","sequence":"first","affiliation":[{"name":"Diyarbakir Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurettin","family":"Okur","sequence":"additional","affiliation":[{"name":"Diyarbakir Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4415-4437","authenticated-orcid":false,"given":"Ozlem","family":"G\u00fcl","sequence":"additional","affiliation":[{"name":"Diyarbakir Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhat","family":"Samanc\u0131","sequence":"additional","affiliation":[{"name":"Diyarbak\u0131r Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"S1047951125111104_ref7","first-page":"303","article-title":"A formula to estimate the approximate surface area if height and weight be known. 1916","volume":"5","author":"Du Bois","year":"1989","journal-title":"Nutrition"},{"key":"S1047951125111104_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02357-6"},{"key":"S1047951125111104_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12309"},{"key":"S1047951125111104_ref24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00346.2004"},{"key":"S1047951125111104_ref26","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002656"},{"key":"S1047951125111104_ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.3.435.435"},{"key":"S1047951125111104_ref3","first-page":"213","article-title":"Iron overload thalassemic cardiomyopathy: iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity","volume":"25","author":"Lekawanvijit","year":"2009","journal-title":"Can J Cardiol"},{"key":"S1047951125111104_ref40","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2822"},{"key":"S1047951125111104_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2019.12.011"},{"key":"S1047951125111104_ref31","first-page":"12","article-title":"Right ventricular function in chronic heart failure: from the diagnosis to the therapeutic approach","volume":"7","author":"Monitillo","year":"2020","journal-title":"J Cardiovasc Dev Dis"},{"key":"S1047951125111104_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2008.07.016"},{"key":"S1047951125111104_ref43","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.48.3.430"},{"key":"S1047951125111104_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2008.07.030"},{"key":"S1047951125111104_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2001.tb00101.x"},{"key":"S1047951125111104_ref20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.108.789081"},{"key":"S1047951125111104_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6363(96)00081-8"},{"key":"S1047951125111104_ref33","doi-asserted-by":"publisher","DOI":"10.1159\/000092344"},{"key":"S1047951125111104_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12208"},{"key":"S1047951125111104_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-008-9240-1"},{"key":"S1047951125111104_ref47","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(08)70004-3"},{"key":"S1047951125111104_ref28","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01144.2001"},{"key":"S1047951125111104_ref2","doi-asserted-by":"publisher","DOI":"10.3109\/03630260903347526"},{"key":"S1047951125111104_ref22","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.72.3.671"},{"key":"S1047951125111104_ref34","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9319832"},{"key":"S1047951125111104_ref38","doi-asserted-by":"publisher","DOI":"10.30565\/medalanya.955688"},{"key":"S1047951125111104_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2021.05.015"},{"key":"S1047951125111104_ref27","first-page":"63","article-title":"Complications of endomyocardial biopsy in heart transplant patients","volume":"12","author":"Baraldi-Junkins","year":"1993","journal-title":"J Heart Lung Transplant"},{"key":"S1047951125111104_ref35","first-page":"1685","article-title":"The correlation between ferritin levels and QTc interval in children with transfusion dependent thalassemia","volume":"7","author":"Dharmawan","year":"2025","journal-title":"J Med Pharm Chem Res"},{"key":"S1047951125111104_ref46","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.1982"},{"key":"S1047951125111104_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2013.01.003"},{"key":"S1047951125111104_ref44","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S354574"},{"key":"S1047951125111104_ref39","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/170510"},{"key":"S1047951125111104_ref32","doi-asserted-by":"publisher","DOI":"10.1177\/1479972306070376"},{"key":"S1047951125111104_ref42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.007641"},{"key":"S1047951125111104_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2016.09.008"},{"key":"S1047951125111104_ref11","first-page":"1","article-title":"The QT interval","volume":"43","author":"Bednar","year":"2001","journal-title":"Prog Cardiovasc Dis"},{"key":"S1047951125111104_ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000092563"},{"key":"S1047951125111104_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2011.01579.x"},{"key":"S1047951125111104_ref45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2009.01314.x"},{"key":"S1047951125111104_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.05.023"},{"key":"S1047951125111104_ref23","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12444"},{"key":"S1047951125111104_ref37","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20679"},{"key":"S1047951125111104_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.12.008"},{"key":"S1047951125111104_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.03.019"},{"key":"S1047951125111104_ref36","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951120002498"},{"key":"S1047951125111104_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00713-7"},{"key":"S1047951125111104_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2017.07.019"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951125111104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:36:50Z","timestamp":1783082210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951125111104\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1047951125111104"],"URL":"https:\/\/doi.org\/10.1017\/s1047951125111104","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}