{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:14:16Z","timestamp":1785406456795,"version":"3.56.0"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"unspecified","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951126111597_as1\">\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>CHD affect approximately 1% of live births globally and are the most common congenital anomaly. Contemporary data on CHD risk in offspring of affected mothers remains limited. This study evaluated CHD incidence in offspring of mothers with CHD at a southeastern U.S. academic medical centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126111597_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective review of patients with CHD who received prenatal care between 2015 and 2023 at a multidisciplinary Cardio-Obstetrics clinic. Patients with acquired heart disease, syndromic or inherited CHD, and deliveries at outside hospitals with missing delivery data were excluded. The primary outcome was infant CHD incidence, confirmed by postnatal echocardiography. Secondary outcomes were neonatal intensive care unit admission, early in-hospital cardiac surgery, and in-hospital infant mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126111597_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 186 mothers with 195 pregnancies and 198 infants were included. CHD was diagnosed in 16 infants (8.1%), most commonly ventricular septal defect. Of affected infants, none required early in-hospital surgery, and one experienced in-hospital mortality, though this infant had severe extracardiac anomalies concerning an underlying genetic syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126111597_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The incidence of CHD among offspring of mothers with CHD in our cohort was higher than the general population; however, the majority of defects were non-critical and did not require early intervention. These findings offer important context for prenatal counselling and tailored fetal\/neonatal echocardiography screening in this high-risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951126111597","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T07:01:48Z","timestamp":1772175708000},"page":"275-279","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["CHD incidence in offspring of mothers with non-inherited and non-syndromic forms of CHD: a single-centre retrospective cohort study"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0467-6740","authenticated-orcid":false,"given":"Syed Anas","family":"Hyder","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack Earl","family":"Simmons","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Alabama at Birmingham Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Emerson","family":"Scheinuk","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7674-9796","authenticated-orcid":false,"given":"Rachel","family":"Sinkey","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc G.","family":"Cribbs","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"S1047951126111597_ref3","volume-title":"Human Genetics of Congenital Heart Defects. Congenital Heart Diseases: The Broken Heart Advances in Experimental Medicine and Biology","author":"Wilsdon","year":"2024"},{"key":"S1047951126111597_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.12.005"},{"key":"S1047951126111597_ref4","doi-asserted-by":"crossref","first-page":"e2022056415C","DOI":"10.1542\/peds.2022-056415C","article-title":"Care of the fetus with congenital cardiovascular disease: from diagnosis to delivery","volume":"150","author":"Haxel","year":"2022","journal-title":"Pediatrics"},{"key":"S1047951126111597_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/2047487314551547"},{"key":"S1047951126111597_ref16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309302"},{"key":"S1047951126111597_ref12","unstructured":"12. Nonsyndromic Congenital Heart Disease Panel. Prevention genetics. 2025. https:\/\/www.preventiongenetics.com\/testInfo?val=Nonsyndromic-Congenital-Heart-Disease-Panel."},{"key":"S1047951126111597_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-54628-3_51"},{"key":"S1047951126111597_ref17","first-page":"33","volume-title":"Congenital Heart Defects and Pulmonary Arterial Hypertension: Genes, Environment and Heredity","author":"Kerstjens-Frederiske","year":"2013"},{"key":"S1047951126111597_ref9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-052151"},{"key":"S1047951126111597_ref10","doi-asserted-by":"publisher","DOI":"10.5694\/mja12.10811"},{"key":"S1047951126111597_ref22","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1002\/pd.5557","article-title":"The added value of screening fetal echocardiography after normal cardiac views on a detailed ultrasound","volume":"39","author":"Cawyer","year":"2019","journal-title":"Prenat Diagn"},{"key":"S1047951126111597_ref11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/CIRCULATIONAHA.123.064400","article-title":"Survival from birth until young adulthood among individuals with congenital heart defects: CH STRONG","volume":"148","author":"Downing","year":"2023","journal-title":"Circulation"},{"key":"S1047951126111597_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-019-02083-6"},{"key":"S1047951126111597_ref19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/joa3.12717","article-title":"European Heart Rhythm Association (EHRA)\/Heart Rhythm Society (HRS)\/Asia Pacific Heart Rhythm Society (APHRS)\/Latin American Heart Rhythm Society (LAHRS) expert consensus statement on the state of genetic testing for cardiac diseases","volume":"38","author":"Wilde","year":"2022","journal-title":"J Arrhythm"},{"key":"S1047951126111597_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2015.02.009"},{"key":"S1047951126111597_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001054"},{"key":"S1047951126111597_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2023.04.014"},{"key":"S1047951126111597_ref15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.121.003533"},{"key":"S1047951126111597_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz009"},{"key":"S1047951126111597_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.07.014"},{"key":"S1047951126111597_ref20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.gocm.2022.07.005","article-title":"Genetic detection of congenital heart disease","volume":"2","author":"Sumathi","year":"2022","journal-title":"Gynecol Obstetrics Clin Med"},{"key":"S1047951126111597_ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252343"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126111597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:36:59Z","timestamp":1783082219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126111597\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1047951126111597"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126111597","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}