{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:56:46Z","timestamp":1785430606705,"version":"3.56.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"unspecified","delay-in-days":30,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951126111664_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The KONAR-MF\u2122 occluder, with its flexible medium-profile design, has broadened the feasibility of transcatheter closure of muscular ventricular septal defects, particularly in infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126111664_as2\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess feasibility, safety, techniques, and outcomes of muscular ventricular septal defect closure using the KONAR-MF\u2122 occluder in a multicentre paediatric cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126111664_as3\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective review was conducted at three tertiary paediatric cardiac centres (2018\u20132024). Patient demographics, ventricular septal defect characteristics, procedural approaches, and follow-up outcomes were analysed. Device implantation was performed via retrograde, antegrade, transseptal, or hybrid approaches under fluoroscopic and echocardiographic guidance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126111664_as4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifty patients (54 devices) were included (median age: 48 months [interquartile range 12\u201396]; weight: 12 kg [interquartile range 7.5\u201323]), including 14 infants (9 &lt; 7 kg). Indications were failure to thrive (46%), heart failure (28%), recurrent infections (12%), and postoperative residual ventricular septal defect (14%). The mean ventricular septal defect size was 5.8 \u00b1 2 mm. Median fluoroscopy time was 18 minutes (range: 3\u201371). Residual shunts were present in 18% immediately, reducing to 9% at one week and resolving by three months. Mild, transient tricuspid regurgitation occurred in 14%. Over a median 9-month follow-up (range 1\u201360), no cases of heart block or haemolysis occurred. One embolisation required surgical retrieval. Pulmonary artery pressure decreased significantly (37 \u00b1 13.4 to 19 \u00b1 3.8 mmHg,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126111664_as5\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Transcatheter closure of muscular ventricular septal defects with the KONAR-MF\u2122 occluder is safe, effective, and versatile across paediatric age groups, including infants and postoperative cases. High success rates, minimal complications, and favourable short- to mid-term outcomes support its use in routine practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951126111664","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T01:42:24Z","timestamp":1774921344000},"page":"488-493","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Transcatheter and hybrid closure of muscular ventricular septal defects using the KONAR-MF\u2122 occluder: a multicentre paediatric experience in India"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-165X","authenticated-orcid":false,"given":"Usha M.K.","family":"Sastry","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00h7p4v21","id-type":"ROR","asserted-by":"publisher"}],"name":"Sri Jayadeva Institute of Cardiovascular Sciences and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-8870","authenticated-orcid":false,"given":"Nageswara Rao","family":"Koneti","sequence":"additional","affiliation":[{"name":"Rainbow Children\u2019s Healthcare Society"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhargavi","family":"Dhulipudi","sequence":"additional","affiliation":[{"name":"Rainbow Children\u2019s Healthcare Society"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navaneetha","family":"Sasikumar","sequence":"additional","affiliation":[{"name":"Amrita Institute of Medical Sciences and Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Bakhru","sequence":"additional","affiliation":[{"name":"Rainbow Children\u2019s Healthcare Society"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakthi","family":"Saravanan","sequence":"additional","affiliation":[{"name":"Amrita Institute of Medical Sciences and Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayranganath","family":"Mahimarangaiah","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00h7p4v21","id-type":"ROR","asserted-by":"publisher"}],"name":"Sri Jayadeva Institute of Cardiovascular Sciences and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4343-0951","authenticated-orcid":false,"given":"Raman Krishna","family":"Kumar","sequence":"additional","affiliation":[{"name":"Amrita Institute of Medical Sciences and Research Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"S1047951126111664_ref11","first-page":"91","article-title":"Device closure of muscular ventricular septal defects in infants less than one year of age using the amplatzer devices: feasibility and 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India","volume":"15","author":"Ghosh","year":"2023","journal-title":"Cureus"},{"key":"S1047951126111664_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.06.020"},{"key":"S1047951126111664_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-020-02315-0"}],"container-title":["Cardiology in the 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