{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:00:36Z","timestamp":1785420036200,"version":"3.56.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"unspecified","delay-in-days":26,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951126111755_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Infective endocarditis remains a serious condition. Patients with CHD are particularly susceptible due to structural abnormalities and repeated interventions. However, comparative data on infective endocarditis outcomes in patients with and without CHD stratified by age group remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126111755_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We searched PubMed, Embase, and Cochrane for cohort studies comparing infective endocarditis outcomes in CHD versus non-CHD. Risk ratios with 95% confidence intervals were pooled using random-effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126111755_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We included six observational cohort studies encompassing 180,194 patients, of whom 176,882 were adults and 3312 were children. Overall, 65% of the population were male. Patients with CHD tended to be younger and carried a lower comorbidity burden. CHD was associated with lower in-hospital mortality risk in adults (RR 0.42; 95% CI 0.34\u20130.53;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), whereas children with CHD demonstrated higher risk (RR 1.59; 95% CI 1.08 to 2.32;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02).\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      infective endocarditis was more common in adults with CHD (RR 1.28; 95% CI 1.09 to 1.50;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01), while\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      aureus infective endocarditis was less common in both adults (RR 0.71; 95% CI 0.58 to 0.88;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01) and paediatric (RR 0.73; 95% CI 0.64 to 0.84;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01) CHD patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126111755_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      In this meta-analysis, mortality patterns in CHD varied by age, with lower mortality in adults and higher mortality in children.\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      infective endocarditis was more common in adults with CHD, whereas\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      aureus was less frequent across CHD age groups. These results highlight the need for age-specific and individualised endocarditis management in CHD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951126111755","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:35:22Z","timestamp":1774604122000},"page":"509-518","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Infective endocarditis in patients with and without CHD: a meta-analysis of age-specific outcomes"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7606-752X","authenticated-orcid":false,"given":"Juan","family":"Pinilla","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037p13h95","id-type":"ROR","asserted-by":"publisher"}],"name":"CES University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brijesh","family":"Baral","sequence":"additional","affiliation":[{"name":"Birat Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Rosseto","sequence":"additional","affiliation":[{"name":"Hospital Icara\u00ed"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrushali","family":"Shelar","sequence":"additional","affiliation":[{"name":"CUNY Graduate School of Public Health & Health Policy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaraith","family":"Coy","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037p13h95","id-type":"ROR","asserted-by":"publisher"}],"name":"CES University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Neves","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrunalini","family":"Dandamudi","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"do Carmo Jorge","sequence":"additional","affiliation":[{"name":"Hospital Sirio Libanes"},{"name":"Hospital Israelita Albert Einstein"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Hospital Sirio Libanes"},{"name":"Hospital Israelita Albert Einstein"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"S1047951126111755_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad193"},{"key":"S1047951126111755_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.10.136"},{"key":"S1047951126111755_ref27","first-page":"625","article-title":"More than just the heart: transition and psychosocial issues in adult congenital heart disease","volume":"33","author":"Kovacs","year":"2015","journal-title":"Cardiol Clin"},{"key":"S1047951126111755_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2023.01.012"},{"key":"S1047951126111755_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-022-01959-3"},{"key":"S1047951126111755_ref28","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000296"},{"key":"S1047951126111755_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2024.132237"},{"key":"S1047951126111755_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.06.027"},{"key":"S1047951126111755_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.183216"},{"key":"S1047951126111755_ref16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215071"},{"key":"S1047951126111755_ref20","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000298"},{"key":"S1047951126111755_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu871"},{"key":"S1047951126111755_ref13","volume-title":"R: A Language and Environment for Statistical Computing","year":"2021"},{"key":"S1047951126111755_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.06.026"},{"key":"S1047951126111755_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"S1047951126111755_ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001827"},{"key":"S1047951126111755_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.08.035"},{"key":"S1047951126111755_ref12","unstructured":"12. Wells, G , Shea, B , O\u2019Connell, D , et\u00a0al. The Newcastle\u2013Ottawa scale (NOS) for assessing the quality of non-randomized studies in meta-analysis. 2000."},{"key":"S1047951126111755_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq032"},{"key":"S1047951126111755_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.24.3012"},{"key":"S1047951126111755_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae548"},{"key":"S1047951126111755_ref26","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000969"},{"key":"S1047951126111755_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2019.05.014"},{"key":"S1047951126111755_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311650"},{"key":"S1047951126111755_ref2","first-page":"2048","article-title":"Incidence, risk factors, and predictors of infective endocarditis in adult congenital heart disease: focus on the use of prosthetic material","volume":"38","author":"Kuijpers","year":"2017","journal-title":"Eur Heart J"},{"key":"S1047951126111755_ref10","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (Updated February 2022)","author":"Higgins","year":"2022"},{"key":"S1047951126111755_ref25","doi-asserted-by":"publisher","DOI":"10.1086\/383035"},{"key":"S1047951126111755_ref15","first-page":"320","article-title":"Predictive factors of death associated with infective endocarditis in adult patients with congenital heart disease","volume":"10","author":"Ly","year":"2021","journal-title":"Eur Heart J Acute Cardiovasc Care"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126111755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:09:06Z","timestamp":1776085746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126111755\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1047951126111755"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126111755","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}