{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:57:57Z","timestamp":1785427077692,"version":"3.56.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":31,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,3]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Studies assessing the effect of preoperative iron supplementation in paediatric cardiac surgery are limited and yield conflicting data.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n The study aimed to evaluate the effect of preoperative oral iron supplementation on allogeneic blood transfusion after cardiac surgery for acyanotic CHD.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n This was a prospective, open-label, outcome assessor-blinded, randomised clinical trial performed in a large tertiary care centre in India. Children (haemoglobin <13 gm\/dl) with acyanotic CHD were recruited for the study. Children in the intervention arm received colloidal iron (3 mg\/kg), folic acid, and cyanocobalamin according to body weight for at least 7 days before cardiac surgery. The primary outcome was the amount of allogeneic blood transfusion, while secondary outcome measures were the duration of mechanical ventilation and ICU stay.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of eighty-six children (43 in each arm) completed the trials. A total of 43 children received iron supplementation for a minimum of 1 month. The haemoglobin level improved by 1.3 gm\/dl immediately before the cardiac surgery in the intervention arm. The allogeneic blood transfusions (ml\/kg) median (IQR) were significantly lower in the intervention group (5 (0\u20138) vs 10 (8\u201312);\n p<\/jats:italic>\n < 0.01). Furthermore, total cumulative allogeneic blood transfusion was also significantly lower in the intervention arm (60 ml; (0\u2013100) vs 100 ml; (70\u2013140);\n p<\/jats:italic>\n < 0.001). The duration of mechanical ventilation, ICU stay, and hospital stay was significantly lower in the intervention arm.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Preoperative oral iron supplementation significantly reduces the need for allogeneic blood transfusion in children undergoing cardiac surgery for acyanotic heart disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/s1047951126111858","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:05:43Z","timestamp":1775034343000},"page":"538-544","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Effect of preoperative oral iron supplementation on postoperative outcomes in children with acyanotic congenital heart disease undergoing cardiac surgery: a pragmatic randomised clinical trial"],"prefix":"10.1017","volume":"36","author":[{"given":"Abishek","family":"Murugaiyan","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02fq2px14","id-type":"ROR","asserted-by":"publisher"}],"name":"Jawaharlal Institute of Postgraduate Medical Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8968-9216","authenticated-orcid":false,"given":"Ajay Kumar","family":"Jha","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02fq2px14","id-type":"ROR","asserted-by":"publisher"}],"name":"Jawaharlal Institute of Postgraduate Medical Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyen","family":"Parida","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02fq2px14","id-type":"ROR","asserted-by":"publisher"}],"name":"Jawaharlal Institute of Postgraduate Medical Education and 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