{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:11:09Z","timestamp":1785409869130,"version":"3.56.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"unspecified","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951126112062_as1\">\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>\n                      Cardiac complications significantly contribute to mortality in Duchenne muscular dystrophy patients. Early detection of cardiac involvement is crucial for optimising therapeutic interventions. This study aimed to evaluate the role of\n                      <jats:italic>N<\/jats:italic>\n                      -terminal pro-brain natriuretic peptide in detecting cardiac involvement, as assessed by real-time three-dimensional (four-dimensional) and three-dimensional speckle-tracking echocardiography in patients with Duchenne muscular dystrophy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112062_as2\">\n                    <jats:title>Material and methods:<\/jats:title>\n                    <jats:p>\n                      This cross-sectional study enrolled individuals under 21 years. Participants underwent clinical evaluation, real-time three-dimensional echocardiography, three-dimensional speckle-tracking echocardiography, and simultaneous measurement of serum\n                      <jats:italic>N<\/jats:italic>\n                      -terminal pro-brain natriuretic peptide levels. Correlation analysis between echocardiographic parameters and\n                      <jats:italic>N<\/jats:italic>\n                      -terminal pro-brain natriuretic peptide was performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112062_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study comprised 38 Duchenne muscular dystrophy patients with a mean age of 9.40 \u00b1 4.13 years. Moderate significant correlations were observed between\n                      <jats:italic>N<\/jats:italic>\n                      -terminal pro-brain natriuretic peptide and echocardiographic parameters, including basal anterolateral and inferolateral longitudinal strain, apical septal longitudinal strain, and basal anterolateral and inferolateral radial strain (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). Subgroup analysis based on\n                      <jats:italic>N<\/jats:italic>\n                      -terminal pro-brain natriuretic peptide (&lt;125 pg\/ml vs. \u2265125 pg\/ml) revealed impaired basal anterolateral longitudinal strain in patients with high\n                      <jats:italic>N<\/jats:italic>\n                      -terminal pro-brain natriuretic peptide.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112062_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      This is the first study that includes\n                      <jats:italic>N<\/jats:italic>\n                      -terminal pro-brain natriuretic peptide in conjunction with real-time three-dimensional echocardiography and three-dimensional speckle-tracking echocardiography for assessing cardiac involvement in Duchenne muscular dystrophy patients. The observed correlations between\n                      <jats:italic>N<\/jats:italic>\n                      -terminal pro-brain natriuretic peptide levels and regional contraction parameters hold promise for its relevance as a biomarker for cardiac dysfunction. Prospective studies with a larger population with a broader range of disease severity are necessary in patients with Duchenne muscular dystrophy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951126112062","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:44:02Z","timestamp":1775807042000},"page":"724-730","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Could N-terminal pro-brain natriuretic peptide predict cardiac involvement in children with Duchenne muscular dystrophy as detected by real-time three-dimensional (four-dimensional) and speckle-tracking echocardiography?"],"prefix":"10.1017","volume":"36","author":[{"given":"Enes","family":"Kaynak","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05j1qpr59","id-type":"ROR","asserted-by":"publisher"}],"name":"Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6579-0670","authenticated-orcid":false,"given":"Ayse G\u00fcler","family":"Ero\u011flu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05j1qpr59","id-type":"ROR","asserted-by":"publisher"}],"name":"Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u011furcan","family":"Say\u0131l\u0131","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda S\u00f6nmez","family":"Kurukaya","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05j1qpr59","id-type":"ROR","asserted-by":"publisher"}],"name":"Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Y\u00fcksel Karatoprak","sequence":"additional","affiliation":[{"name":"Istanbul Medeniyet Universitesi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Salt\u0131k","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05j1qpr59","id-type":"ROR","asserted-by":"publisher"}],"name":"Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"S1047951126112062_ref24","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15453"},{"key":"S1047951126112062_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-001-0040-0"},{"key":"S1047951126112062_ref19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-88"},{"key":"S1047951126112062_ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-022-02996-8"},{"key":"S1047951126112062_ref32","doi-asserted-by":"publisher","DOI":"10.1186\/s12947-020-00209-y"},{"key":"S1047951126112062_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/jalm\/jfaa090"},{"key":"S1047951126112062_ref29","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013648"},{"key":"S1047951126112062_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32160-8"},{"key":"S1047951126112062_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(76)80053-6"},{"key":"S1047951126112062_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.57.6.1122"},{"key":"S1047951126112062_ref30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.122.010040"},{"key":"S1047951126112062_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-020-00613-8"},{"key":"S1047951126112062_ref23","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951122001408"},{"key":"S1047951126112062_ref10","first-page":"121","article-title":"Improvement of survival in Duchenne muscular dystrophy: retrospective analysis of 835 patients","volume":"31","author":"Passamano","year":"2012","journal-title":"Acta Myol"},{"key":"S1047951126112062_ref2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2448"},{"key":"S1047951126112062_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2025.06.003"},{"key":"S1047951126112062_ref11","first-page":"117","article-title":"Survival in Duchenne muscular dystrophy","volume":"31","author":"Rall","year":"2012","journal-title":"Acta Myol"},{"key":"S1047951126112062_ref20","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.2183"},{"key":"S1047951126112062_ref27","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14314"},{"key":"S1047951126112062_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"S1047951126112062_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"S1047951126112062_ref6","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.11.949"},{"key":"S1047951126112062_ref28","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l223"},{"key":"S1047951126112062_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.10.017"},{"key":"S1047951126112062_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(02)00140-2"},{"key":"S1047951126112062_ref21","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1904"},{"key":"S1047951126112062_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01682-5"},{"key":"S1047951126112062_ref25","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951121005126"},{"key":"S1047951126112062_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/jalm\/jfad024"},{"key":"S1047951126112062_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.03.001"},{"key":"S1047951126112062_ref5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.141721"},{"key":"S1047951126112062_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/0883073810371004"},{"key":"S1047951126112062_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2013.06.002"},{"key":"S1047951126112062_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23808"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126112062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:55:47Z","timestamp":1780397747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126112062\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1047951126112062"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126112062","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}