{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:33:27Z","timestamp":1785429207622,"version":"3.56.0"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"unspecified","delay-in-days":22,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951126112189_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the prevalence and clinical implications of QT interval prolongation and other electrocardiographic changes in paediatric patients with rheumatic diseases using hydroxychloroquine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112189_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective and prospective, observational, and analytical study conducted at a centre of perinatology and paediatrics in Rio de Janeiro, Brazil. A total of 26 evaluations of patients \u226418 years old on hydroxychloroquine were included, all following paediatric rheumatology and cardiology services. Patients were included if they had been receiving hydroxychloroquine for at least six months and had complete clinical records; those with pre-existing cardiac conditions unrelated to hydroxychloroquine were excluded. Clinical, demographic, and electrocardiographic data were collected from medical records using standardised protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112189_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The corrected QT interval was manually measured on 12-lead electrocardiograms and analysed in relation to cumulative drug dose. All electrocardiograms were reviewed independently by two cardiologists to ensure accuracy of corrected QT interval measurements, and discrepancies were resolved by consensus. Most patients were female (76.9%), and systemic lupus erythematosus was the most prevalent diagnosis (88.9%). The cumulative hydroxychloroquine dose ranged from 12 to 447.6 g (mean: 223 g). Corrected QT interval values ranged from 377 to 454 ms (mean: 413 ms). Correlation analysis between cumulative dose and corrected QT interval showed a weak negative association (r = \u20130.24; p = 0.338), not statistically significant. Simple linear regression confirmed no association between variables (R\n                      <jats:sup>2<\/jats:sup>\n                      = 5.7%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112189_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this cohort of paediatric patients with rheumatic diseases, no significant association was observed between cumulative hydroxychloroquine use and QT interval prolongation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951126112189","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:54:07Z","timestamp":1776945247000},"page":"690-694","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Electrocardiographic findings in paediatric patients with rheumatic diseases using hydroxychloroquine"],"prefix":"10.1017","volume":"36","author":[{"given":"Alan Lima","family":"Araujo","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02k5swt12","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal do Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sao Paulo Escola Paulista de Medicina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isadora Souza","family":"Rufino","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Rodrigues","family":"Fonseca","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02k5swt12","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal do Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Cristine","family":"F\u00e9lix","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02k5swt12","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal do Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio Roberto","family":"Sztajnbok","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02k5swt12","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal do Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1491-4877","authenticated-orcid":false,"given":"Nathalie Jeanne","family":"Bravo-valenzuela","sequence":"additional","affiliation":[{"name":"Pedicor"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"S1047951126112189_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2020.06.022"},{"key":"S1047951126112189_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-020-00785-4"},{"key":"S1047951126112189_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216114"},{"key":"S1047951126112189_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951120002425"},{"key":"S1047951126112189_ref15","doi-asserted-by":"publisher","DOI":"10.1590\/S0482-50042003000500003"},{"key":"S1047951126112189_ref23","unstructured":"23. Woosley, RL , Heise, CW , Gallo, T , Tate, J , Woosley, D , Romero, KA. QTdrugs List, AZCERT, Inc. 1822 Innovation Park Dr., Oro Valley, AZ 85755. www.CredibleMeds.org. Accessed 10 July 2019."},{"key":"S1047951126112189_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2015.07.004"},{"key":"S1047951126112189_ref11","unstructured":"11. Orienta\u00e7\u00f5es da Sociedade Brasileira de Reumatologia para Pacientes com Doen\u00e7as Reum\u00e1ticas em uso de Cloroquina e Hidroxicloroquina, https:\/\/www.reumatologia.org.br\/orientacoes-ao-paciente\/orientacoes-da-sociedade-brasileira-de-reumatologia-para-pacientes-com-doencas-reumaticas-em-uso-de-cloroquina-e-hidroxicloroquina\/. acesso em 20 de dezembro de 2023."},{"key":"S1047951126112189_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.03.024"},{"key":"S1047951126112189_ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032426"},{"key":"S1047951126112189_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2014.09.008"},{"key":"S1047951126112189_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205139"},{"key":"S1047951126112189_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21664"},{"key":"S1047951126112189_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-216924"},{"key":"S1047951126112189_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215213"},{"key":"S1047951126112189_ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-018-0005-0"},{"key":"S1047951126112189_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2021.04.009"},{"key":"S1047951126112189_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22783"},{"key":"S1047951126112189_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039039"},{"key":"S1047951126112189_ref2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215089"},{"key":"S1047951126112189_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/art.41934"},{"key":"S1047951126112189_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.06.033"},{"key":"S1047951126112189_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpam.2018.12.002"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126112189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:55:33Z","timestamp":1780397733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126112189\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1047951126112189"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126112189","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"\u00a9 The Author(s), 2026 Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}