{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:56:25Z","timestamp":1785405385342,"version":"3.56.0"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"unspecified","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951126112220_as1\">\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Arrhythmic mitral valve prolapse is a rare yet potentially fatal syndrome. Recently, high-risk markers for malignant arrhythmias have been identified in adults with mitral valve prolapse, and a risk stratification scheme has been proposed. Little is known about the prevalence of arrhythmic mitral valve prolapse, the characteristics of the syndrome, and risk markers in children and young adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112220_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A database of a high-volume, tertiary congenital heart defects department was searched to identify all patients with MVP between 2018 and 2025 (8 years). Patients\u2019 characteristics, including arrhythmic risk factors, AMVP diagnosis, and last survival, were noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112220_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 12,955 hospitalised patients, 52 were diagnosed with mitral valve prolapse (0.4%; median age 14y [IQR 6], 35% male). Arrhythmic mitral valve prolapse was diagnosed in 13 patients (25% of the mitral valve prolapse cohort). Phenotypic risk factors were highly prevalent (88.5%), but in the crosstab analysis, only an enlarged left atrium was associated with high-risk arrhythmic events (p = 0.0432). Furthermore, patients with arrhythmic events were significantly older (median 16y) than those without (median 13y; p = 0.019). One patient (2.7%, with concomitant LQTS2) presented with unstable ventricular tachycardia and received an ICD. During a median follow-up of 3 years (IQR 1\u20134.5), all 52 patients were alive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112220_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>One in 250 patients admitted to a tertiary invasive paediatric cardiology department has mitral valve prolapse. Among those with mitral valve prolapse, 1 in 4 presents with arrhythmic mitral valve prolapse. Although risk factors are common, outcomes among young arrhythmic mitral valve prolapse patients appear good. Overlapping with primary electrical disease may flag a worse prognosis. Identification of new risk factors for children is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951126112220","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:34:16Z","timestamp":1776756856000},"page":"695-698","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Arrhythmic mitral valve prolapse: prevalence, characteristics, and high-risk features in children and adolescents"],"prefix":"10.1017","volume":"36","author":[{"given":"Anna","family":"Lenarczyk","sequence":"first","affiliation":[{"name":"Silesian Centre for Heart Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8169-5232","authenticated-orcid":false,"given":"Filip","family":"Tyc","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/005k7hp45","id-type":"ROR","asserted-by":"publisher"}],"name":"Silesian Medical University, Katowice, Silesian Centre for Heart Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rados\u0142aw","family":"Lenarczyk","sequence":"additional","affiliation":[{"name":"Silesian Medical University, Katowice, Silesian Centre for Heart Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Tomasiczek - Santana","sequence":"additional","affiliation":[{"name":"Silesian Centre for Heart Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Grochowina - Major","sequence":"additional","affiliation":[{"name":"Silesian Centre for Heart Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Fiszer","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/005k7hp45","id-type":"ROR","asserted-by":"publisher"}],"name":"Silesian Medical University, Katowice, Silesian Centre for Heart Disease"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"S1047951126112220_ref7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016291"},{"key":"S1047951126112220_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2025.103083"},{"key":"S1047951126112220_ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81648-z"},{"key":"S1047951126112220_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac125"},{"key":"S1047951126112220_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)90059-6"},{"key":"S1047951126112220_ref3","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010584"},{"key":"S1047951126112220_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00474-X"},{"key":"S1047951126112220_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2021.01.007"},{"key":"S1047951126112220_ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907013410101"},{"key":"S1047951126112220_ref2","first-page":"511","article-title":"Prevalence of mitral valve prolapse in ethnic groups","volume":"20","author":"Theal","year":"2004","journal-title":"Can J Cardiol"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126112220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:56:14Z","timestamp":1780397774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126112220\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1047951126112220"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126112220","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}