{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:54:27Z","timestamp":1785412467211,"version":"3.56.0"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"unspecified","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951126112281_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Complex CHDs may impair organ development. One proposed mechanism is an altered relationship between blood flow, oxygen delivery, and subsequent organ growth. In this study, we examined whether fetal lung, intracranial, liver, and kidney volumes differ among fetuses with transposition of the great arteries with an intact ventricular septum, transposition of the great arteries with a ventricular septal defect, and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112281_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Eleven fetuses with transposition of the great arteries (6 with a ventricular septal defect and 5 with an intact ventricular septum) and 22 healthy controls were scanned between 1 and 3 times at gestational age 27\u201338 weeks, using fetal MRI. We measured lung, total intracranial, liver, and kidney volumes and compared fetuses with and without transposition of the great arteries while subsequently correcting for ventricular septal defect\/intact ventricular septum status, estimated fetal weight, and gestational age, using mixed effects regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112281_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fetuses with transposition of the great arteries+intact ventricular septum had significantly larger lung volumes compared to controls. After adjusting for estimated fetal weight and gestational age, median lung volume ratio (transposition of the great arteries+intact ventricular septum vs. controls) was 1.30 (95% CI: 1.08\u20131.57;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005). No difference was found in lung volume between fetuses with transposition of the great arteries+ventricular septal defect and controls. No significant differences in total intracranial, liver, and kidney volumes were found between transposition of the great arteries+ventricular septal defect, transposition of the great arteries+intact ventricular septum, and controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126112281_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this preliminary study, late-gestation fetuses with transposition of the great arteries-intact ventricular septum had a 30% larger lung volume compared with both transposition of the great arteries-ventricular septal defect and healthy controls. Together with existing evidence of higher fetal pulmonary blood flow and increased oxygen saturation in transposition of the great arteries-intact ventricular septum, these findings support a potential link between blood flow, oxygen delivery, and organ growth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951126112281","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:02:27Z","timestamp":1778133747000},"page":"762-767","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Larger lung volumes in fetuses with transposition of the great arteries and an intact ventricular septum compared to heart healthy fetuses and fetuses with transposition of the great arteries and a ventricular septal defect"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8201-8360","authenticated-orcid":false,"given":"Emil","family":"Krogh","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03mchdq19","id-type":"ROR","asserted-by":"publisher"}],"name":"Rigshospitalet"},{"id":[{"id":"https:\/\/ror.org\/040r8fr65","id-type":"ROR","asserted-by":"publisher"}],"name":"Aarhus University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe Gade","family":"Hellmuth","sequence":"additional","affiliation":[{"name":"Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte Staub","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Kelly","sequence":"additional","affiliation":[{"name":"Aarhus University"},{"name":"Aarhus University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Vejlstrup","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Petersen","sequence":"additional","affiliation":[{"name":"Rigshospitalet"},{"name":"Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke E.","family":"Hjortdal","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03mchdq19","id-type":"ROR","asserted-by":"publisher"}],"name":"Rigshospitalet"},{"name":"Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette H.","family":"Lauridsen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/040r8fr65","id-type":"ROR","asserted-by":"publisher"}],"name":"Aarhus University Hospital"},{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"S1047951126112281_ref20","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-317111"},{"key":"S1047951126112281_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23707"},{"key":"S1047951126112281_ref27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006459"},{"key":"S1047951126112281_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034467"},{"key":"S1047951126112281_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21920"},{"key":"S1047951126112281_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(86)90029-0"},{"key":"S1047951126112281_ref22","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310624"},{"key":"S1047951126112281_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92638-7"},{"key":"S1047951126112281_ref19","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2016.1133294"},{"key":"S1047951126112281_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-015-1159-8"},{"key":"S1047951126112281_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4308"},{"key":"S1047951126112281_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-015-1437-4"},{"key":"S1047951126112281_ref15","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"S1047951126112281_ref6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11226740"},{"key":"S1047951126112281_ref28","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19102"},{"key":"S1047951126112281_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-002-0404-0"},{"key":"S1047951126112281_ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-023-07249-5"},{"key":"S1047951126112281_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-014-1269-7"},{"key":"S1047951126112281_ref30","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-023-00497-9"},{"key":"S1047951126112281_ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1073046"},{"key":"S1047951126112281_ref29","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1268431"},{"key":"S1047951126112281_ref2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.109152"},{"key":"S1047951126112281_ref34","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12099"},{"key":"S1047951126112281_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0531-y"},{"key":"S1047951126112281_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.05.046"},{"key":"S1047951126112281_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951124026398"},{"key":"S1047951126112281_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2878-4"},{"key":"S1047951126112281_ref24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.135046"},{"key":"S1047951126112281_ref35","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23762"},{"key":"S1047951126112281_ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191319"},{"key":"S1047951126112281_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs281"},{"key":"S1047951126112281_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6893"},{"key":"S1047951126112281_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13724"},{"key":"S1047951126112281_ref26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.865568"},{"key":"S1047951126112281_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14677"},{"key":"S1047951126112281_ref36","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2469"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126112281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:56:15Z","timestamp":1780397775000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126112281\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1047951126112281"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126112281","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}