{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:01:39Z","timestamp":1785402099541,"version":"3.56.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"unspecified","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951126113225_as1\">\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Emerging evidence suggests that an impaired foetal environment\u2014defined as maternal factors such as hypertensive disorders and diabetes\u2014might contribute to outcomes in neonates with CHD. With this multicentre study, we prospectively collected data regarding impaired foetal environment to assess the impact on mortality in two ventricle and single ventricle neonates with CHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126113225_as2\">\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>A module of prospectively collected maternal-foetal environment data was linked to established Pediatric Cardiac Critical Care Consortium data from June 2019 to July 2020. All neonates undergoing cardiothoracic surgery were included in this study. The outcome was in-hospital mortality. The primary predictor was the degree of impaired foetal environment defined as none, mild, or significant based on the presence of maternal hypertensive and glucose homeostasis disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126113225_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were a total of 1913 neonates included in this study from 26 different centres. 218 patients had at least 1 missing impaired foetal environment data field (11.8%). Impaired foetal environment was not associated with increased mortality; however, there was a strong trend in the preterm single ventricular population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126113225_as4\">\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>While the overall cohort did not demonstrate a statistically significant relationship between impaired foetal environment and mortality, a notable trend emerged among preterm infants with single-ventricle physiology, suggesting increased mortality associated with more severe impaired foetal environment. The absence of statistical significance in this subgroup is likely attributable to the limited sample size and the substantial proportion of missing data highlighting the challenges of the mother-baby dyad in data collections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951126113225","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:05:03Z","timestamp":1779174303000},"page":"923-930","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Impact of impaired foetal maternal environment on neonates with CHD: are we ready for the mother-baby dyad?"],"prefix":"10.1017","volume":"36","author":[{"given":"Jill","family":"Savla","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Schumacher","sequence":"additional","affiliation":[{"name":"C.S. Mott Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Mikesell","sequence":"additional","affiliation":[{"name":"C.S. Mott Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousumi","family":"Banerjee","sequence":"additional","affiliation":[{"name":"University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Ball","sequence":"additional","affiliation":[{"name":"The Ohio State University and Nationwide Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Bhat","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital and Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarti","family":"Bhat","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital, University of Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Chan","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital, University of Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4776-0483","authenticated-orcid":false,"given":"Paulomi","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine, Riley Hospital for Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah U.","family":"Frank","sequence":"additional","affiliation":[{"name":"University of Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Killen","sequence":"additional","affiliation":[{"name":"Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Vanderbilt University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-7810","authenticated-orcid":false,"given":"Anita","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Children\u2019s National Heart Institute, Children\u2019s National Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshitij","family":"Mistry","sequence":"additional","affiliation":[{"name":"Boston Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-4569","authenticated-orcid":false,"given":"Tara M.","family":"Neumayr","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angira","family":"Patel","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Savorgnan","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital and Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Son","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dala","family":"Zakaria","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Arkansas Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Tabbutt","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"University of California San 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}