{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:16:48Z","timestamp":1785424608218,"version":"3.56.0"},"reference-count":7,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"unspecified","delay-in-days":44,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We report the case of an 8-year-old boy with unrepaired cyanotic CHD who developed pheochromocytoma and presented with hypertensive heart failure. Imaging revealed a tumour in the right adrenal gland. A genetic analysis identified a somatic\n                    <jats:italic>EPAS1<\/jats:italic>\n                    mutation. This case highlights the potential for early pheochromocytoma development in patients with unrepaired CHD and severe cyanosis. This case provides a hypothesis-generating observation suggesting that chronic hypoxia may act synergistically with a pseudohypoxia mutation, potentially leading to an earlier-than-expected presentation of pheochromocytoma.\n                  <\/jats:p>","DOI":"10.1017\/s1047951126113237","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:34:47Z","timestamp":1778834087000},"page":"876-878","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Early-onset pheochromocytoma with a somatic\n                    <i>EPAS1<\/i>\n                    mutation in an 8-year-old boy with unrepaired pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries"],"prefix":"10.1017","volume":"36","author":[{"given":"Haruna","family":"Egashira","sequence":"first","affiliation":[{"name":"University of Tsukuba Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Hosaka","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02956yf07","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medicine, University of Tsukuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-3935","authenticated-orcid":false,"given":"Yoshihiro","family":"Nozaki","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02956yf07","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute of Medicine, University of Tsukuba"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"S1047951126113237_ref3","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-24-0943"},{"key":"S1047951126113237_ref7","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0256"},{"key":"S1047951126113237_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/oto2.112"},{"key":"S1047951126113237_ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3863"},{"key":"S1047951126113237_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2025.101772"},{"key":"S1047951126113237_ref2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac362"},{"key":"S1047951126113237_ref4","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad311"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126113237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:56:18Z","timestamp":1780397778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126113237\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1047951126113237"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126113237","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}