{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:25:38Z","timestamp":1793762738943,"version":"4.6.1"},"reference-count":8,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"unspecified","delay-in-days":4,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":4,"URL":"https:\/\/www.cambridge.org\/tdm\/tdmrep-policy.json"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n We implemented a quality improvement initiative to optimise the outpatient medication regimen after paediatric cardiac surgery. A previous trial that limited furosemide found no readmissions for pleural effusion but an increase in pericardial effusions. A similar quality improvement project had implemented prophylactic non-steroidal anti-inflammatory drugs and found a decrease in readmissions for pericardial effusion. We used these results to design an outpatient medication regimen that minimises furosemide and uses only targeted ibuprofen and report readmission rates from this project.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Single-centre analysis of outcomes since the adoption of a quality improvement initiative aiming to limit outpatient diuretics (\u22645 days) while using targeted ibuprofen to prevent pericardial effusion readmissions.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Two hundred and one patients were eligible for analysis. Forty-one patients (20.4%) were prescribed >20 days of diuretics due to compliance failure and were not considered to have received a limited diuretic regimen, leaving 160 patients. Of those, 53 (33.1%) were correctly prescribed targeted ibuprofen based on meeting \u201chigh-risk\u201d criteria. There was one readmission for pleural effusion and 2\/160 (1.3%) readmissions for pericardial effusion. The previous prospective study of limited furosemide without ibuprofen had a pericardial effusion readmission rate of 4\/61 (6.6%) versus the 2\/160 (1.3%) after implementing the regimen described in this report (\n p<\/jats:italic>\n = 0.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n We describe a medication regimen using limited outpatient furosemide without increased readmissions for pleural effusions. Targeted ibuprofen was used for high-risk patients only, and there were fewer readmissions for pericardial effusions than in a previous trial that used furosemide alone.<\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/s1047951126123737","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T08:14:52Z","timestamp":1785917692000},"page":"1621-1625","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Minimising an outpatient medication regimen after paediatric cardiac surgery"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8465-2206","authenticated-orcid":false,"given":"Jamie Smith","family":"Penk","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/015yf2b46","id-type":"ROR","asserted-by":"publisher"}],"name":"Dell Children\u2019s Medical Center of Central Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-4211","authenticated-orcid":false,"given":"Lindsay","family":"Jackson","sequence":"additional","affiliation":[{"name":"Ann & Robert H Lurie Children\u2019s Hospital of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Baptista de Faria","sequence":"additional","affiliation":[{"name":"Ann & Robert H Lurie Children\u2019s Hospital of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Doyle","sequence":"additional","affiliation":[{"name":"Ann & Robert H Lurie Children\u2019s Hospital of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Janus","sequence":"additional","affiliation":[{"name":"Ann & Robert H Lurie Children\u2019s Hospital of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-2835","authenticated-orcid":false,"given":"Rohit Seth","family":"Loomba","sequence":"additional","affiliation":[{"name":"Ann & Robert H Lurie Children\u2019s Hospital of Chicago"},{"name":"Northwestern University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Marino","sequence":"additional","affiliation":[{"name":"Duke Children\u2019s Hospital and Health Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6565-2427","authenticated-orcid":false,"given":"Amy","family":"Lay","sequence":"additional","affiliation":[{"name":"Ann & Robert H Lurie Children\u2019s Hospital of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"S1047951126123737_ref5","first-page":"292","article-title":"The effective treatment of postpericardiotomy syndrome after cardiac operations: a randomized placebo-controlled trial","volume":"100","author":"Horneffer","year":"1990","journal-title":"JTCVS"},{"key":"S1047951126123737_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.1997.tb00097.x"},{"key":"S1047951126123737_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-022-03078-6"},{"key":"S1047951126123737_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-017-0235-3"},{"key":"S1047951126123737_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1540-2"},{"key":"S1047951126123737_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/21501351211049308"},{"key":"S1047951126123737_ref1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2069.64368"},{"key":"S1047951126123737_ref2","doi-asserted-by":"publisher","DOI":"10.1186\/cc1494"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126123737","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126123737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:30:59Z","timestamp":1793759459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126123737\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1047951126123737"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126123737","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}