{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:01:36Z","timestamp":1790600496124,"version":"4.1.0"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>An 11-year-old with Down syndrome, autism, prior atrioventricular septal defect repair, and a transvenous pacemaker presented with prolonged fever and raised inflammatory markers. Eight years prior, she had a group A streptococcal sepsis with infection of an epicardial pacemaker. Echocardiography demonstrated a large vegetation on the right atrioventricular valve, with encasement of the pacemaker lead. Following treatment with intravenous antibiotics, she underwent a right atrioventricular valve repair, vegetation excision, and epicardial pacemaker placement. Post-operative recovering was uneventful. This case highlights the complex, multidisciplinary management of device-related endocarditis in Down syndrome and in CHD.<\/jats:p>","DOI":"10.1017\/s1047951126123828","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:45:52Z","timestamp":1790599552000},"page":"1-2","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Infective endocarditis of the right atrioventricular valve and transvenous pacing lead in a patient with Down syndrome"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0665-9725","authenticated-orcid":false,"given":"Siobhan","family":"Coughlan","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/025qedy81","id-type":"ROR","asserted-by":"publisher"}],"name":"Children\u2019s Health Ireland at Crumlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orla","family":"Franklin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/025qedy81","id-type":"ROR","asserted-by":"publisher"}],"name":"Children\u2019s Health Ireland at Crumlin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"S1047951126123828_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31822d320b"},{"key":"S1047951126123828_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.05.007"},{"key":"S1047951126123828_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.12.001"},{"key":"S1047951126123828_ref8","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11113217"},{"key":"S1047951126123828_ref1","first-page":"7","article-title":"Down syndrome and congenital heart disease: perioperative planning and management","volume":"5","author":"Delany","year":"2021","journal-title":"J Congenit Cardiol"},{"key":"S1047951126123828_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.02.031"},{"key":"S1047951126123828_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04335.x"},{"key":"S1047951126123828_ref4","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2017.03.09"},{"key":"S1047951126123828_ref9","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/S0735-1097(03)00419-4","article-title":"The relative roles of transthoracic compared with transesophageal echocardiography in children with suspected infective endocarditis","volume":"41","author":"Humpl","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"S1047951126123828_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.11.016"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126123828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:45:53Z","timestamp":1790599553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126123828\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":10,"alternative-id":["S1047951126123828"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126123828","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}