{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:55:36Z","timestamp":1790769336151,"version":"4.1.0"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute severe haemolysis following atrial septal defect(ASD) device closure is extremely rare, where precise incidence, underlying aetiologies, and optimal management strategies remain inadequately understood. We report a case of significant haemolysis after transcatheter atrial septal defect closure\u00a0in 10 year old female, possibly related to the interface between the device surface and the high-velocity jet of valvular regurgitation resulting from the abnormal configuration of the device. The presence of a residual shunt, combined with atrioventricular valve regurgitation flow, places pressure on the occluder\u2019s discs, leading to increased erythrocyte fragility and subsequent rupture. In our case, haemolysis was initially conservatively managed with fluids, diuresis, and sodium bicarbonate, and the patient was discharged successfully on the 6\n                    <jats:sup>th<\/jats:sup>\n                    post-procedure day. Surgical retrieval was advised; however, the patient was subsequently lost to follow-up. In this case report, we aim to showcase the pathophysiology, technical pitfalls regarding the procedure and management of acute severe haemolysis that occurred after atrial septal defect device closure. In conclusion, by sharing our clinical experiences and addressing misconceptions and potential risk factors for this serious complication, we aim to provide insights that may enhance future clinical practice and preventive strategies.\n                  <\/jats:p>","DOI":"10.1017\/s1047951126124305","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:02:48Z","timestamp":1790766168000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Post Atrial Septal Defect Device Closure Acute Severe Haemolysis: one hole closed, one valve leaked\u2014A Rare Case Report"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2620-2113","authenticated-orcid":false,"given":"Saurabhi","family":"Das","sequence":"first","affiliation":[{"name":"Health City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2103-8660","authenticated-orcid":false,"given":"Shantanu","family":"Jain","sequence":"additional","affiliation":[{"name":"Health City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruk","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Health City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"S1047951126124305_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(01)00084-7"},{"key":"S1047951126124305_ref12","first-page":"538","article-title":"Clinical course and management strategies for hemolysis after transcatheter closure of patent arterial ducts","volume":"59","author":"Anil","year":"2003","journal-title":"Catheteriz Cardiovasc Interven"},{"key":"S1047951126124305_ref6","first-page":"501","volume-title":"Biomechanics","author":"Blackshear","year":"1972"},{"key":"S1047951126124305_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01431-z"},{"key":"S1047951126124305_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.03.295"},{"key":"S1047951126124305_ref10","first-page":"663","article-title":"Transient renal failure due to hemolysis following transcatheter closure of a muscular VSD using an Amplatzer muscular VSD occluder","volume":"67","author":"Spence","year":"2006","journal-title":"Catheter Cardiovasc Interv"},{"key":"S1047951126124305_ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-019-0728-5"},{"key":"S1047951126124305_ref3","first-page":"623","article-title":"Hemolysis, a rare complication after percutaneous closure of an atrial septal defect","volume":"93","author":"Lambert","year":"2000","journal-title":"Arch Mal Coeur Vaiss"},{"key":"S1047951126124305_ref8","first-page":"783","article-title":"Human red blood cell hemolysis in a turbulent shear flow: contribution of Reynolds shear stresses","volume":"21","author":"Sallam","year":"1984","journal-title":"Biorheology"},{"key":"S1047951126124305_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00589-8"},{"key":"S1047951126124305_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951100009215"},{"key":"S1047951126124305_ref9","first-page":"4","article-title":"Haemolysis after Amplatzer device closure of ventricular septal defect.","volume":"9","author":"Mulvaney","year":"2007","journal-title":"Images Paediatr Cardiology"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126124305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:02:49Z","timestamp":1790766169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126124305\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":12,"alternative-id":["S1047951126124305"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126124305","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}