{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:43:01Z","timestamp":1792651381714,"version":"4.5.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/tdm\/tdmrep-policy.json"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951126124445_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Coronary artery lesions remain a major concern in Kawasaki disease. This study aimed to develop and internally validate a practical nomogram for early identification of children at risk for Coronary artery lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126124445_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively analysed 216 children with Kawasaki disease divided into a training cohort (n = 151) and a validation cohort (n = 65). Coronary artery lesions was defined as early coronary dilatation and\/or coronary aneurysm. XGBoost and SHapley Additive exPlanations were applied to explore age\u2019s nonlinear effect. Predictors were screened via multivariable logistic regression with elastic-net regression for supplementary assessment. Model performance was assessed using receiver operating characteristic analysis, calibration curves, and decision-curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126124445_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall, 46 children (21.3%) developed Coronary artery lesions. SHapley Additive exPlanations analysis identified a U-shaped age-risk pattern with cut-off points at 17 and 58 months. Male sex, age group, fever duration, systemic immune-inflammation index, C-reactive protein\/albumin ratio, and intravenous immunoglobulin resistance were independent Coronary artery lesions risk factors incorporated into the nomogram. The area under the receiver operating characteristic curve reached 0.835 (95% CI 0.804\u20130.867) in the training cohort and 0.818 (95% CI 0.767\u20130.869) in the validation cohort. Calibration and decision-curve analysis confirmed good consistency and favourable clinical net benefit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126124445_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This nomogram integrates routine clinical variables and interpretable machine learning to identify nonlinear age-related Coronary artery lesions risk and provide individualised early risk estimation. External validation in large prospective multicentre cohorts is needed before wide clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951126124445","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:26:26Z","timestamp":1792650386000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["An early risk prediction nomogram for coronary artery lesions in Kawasaki disease: a retrospective cohort study"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5351-872X","authenticated-orcid":false,"given":"Xiaoya","family":"Cong","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/001rahr89","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nantong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Shen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/001rahr89","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nantong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Shen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/001rahr89","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Nantong University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,10,22]]},"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126124445","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126124445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:26:26Z","timestamp":1792650386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126124445\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":0,"alternative-id":["S1047951126124445"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126124445","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}