{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:44:38Z","timestamp":1791888278610,"version":"4.3.4"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951126124457_as1\">\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Patients with functional single ventricle anatomy undergo staged surgical palliation in early childhood culminating in the Fontan procedure whereby the inferior vena cava is connected to the pulmonary artery. Fontan circulation inherently requires elevated central venous pressure to maintain adequate pulmonary blood flow; however, excessive elevation is associated with morbidity and mortality. In adults, a key component of echocardiographic evaluation is the use of a \u201csniff test\u201d as a surrogate of downstream right atrial pressure. This technique has not yet been validated as a measure of pressure assessment in patients with Fontan circulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126124457_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a two-center prospective study of patients with functional single ventricle physiology who had undergone the Fontan procedure and were undergoing previously scheduled transthoracic echocardiogram and cardiac catheterization as part of their standard clinical care. We correlated collapsibility index on echocardiogram with directly obtained Fontan pressure measurements from cardiac catheterization performed the same day.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126124457_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>15 patients were enrolled and analyzed for the study. Collapsibility index demonstrated an inverse correlation with Fontan pressure, (Pearson r = \u22120.72, R2 = 0.51, p = 0.003). Collapsibility index was significantly higher for patients with non-elevated Fontan pressure (45% vs 30%, p = 0.0005). Using a collapsibility index threshold of 35.0% demonstrated a 100% positive predictive value for detecting elevated Fontan pressure (greater than 14 mmHg).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951126124457_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>There was a significant inverse relationship between the collapsibility index and Fontan pressure. These findings may suggest a possible association between collapsibility index and Fontan pressure, warranting further investigation in larger studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951126124457","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:46:13Z","timestamp":1791884773000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Association between the inferior vena cava collapsibility index and Fontan pressure in patients with Fontan physiology: a two-centre prospective pilot study"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0218-3619","authenticated-orcid":false,"given":"Matthew D.","family":"Campbell","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0457zbj98","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Oklahoma Health Sciences Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-9856","authenticated-orcid":false,"given":"Arshid","family":"Mir","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0457zbj98","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Oklahoma Health Sciences Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Behere","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0457zbj98","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Oklahoma Health Sciences Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3350-6839","authenticated-orcid":false,"given":"Jennifer H.","family":"Huang","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Burch","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Alnoor","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Madriago","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"S1047951126124457_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-010-9811-9"},{"key":"S1047951126124457_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)00054-0"},{"key":"S1047951126124457_ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.965989"},{"key":"S1047951126124457_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.04.008"},{"key":"S1047951126124457_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.11.007"},{"key":"S1047951126124457_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"S1047951126124457_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.07.016"},{"key":"S1047951126124457_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.11.061"},{"key":"S1047951126124457_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000696"},{"key":"S1047951126124457_ref17","first-page":"089","article-title":"Echocardiographic measurement of inferior vena cava diameter for estimating central venous pressure in adult Fontan patients","volume":"3","author":"Miyake","year":"2025","journal-title":"Eur Heart J Imaging Methods Pract"},{"key":"S1047951126124457_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.03.058"},{"key":"S1047951126124457_ref5","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2015.11.006"},{"key":"S1047951126124457_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1365"},{"key":"S1047951126124457_ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13089-024-00397-y"},{"key":"S1047951126124457_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.058"},{"key":"S1047951126124457_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.05.039"},{"key":"S1047951126124457_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90711-9"},{"key":"S1047951126124457_ref11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00245.2014"},{"key":"S1047951126124457_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.021"},{"key":"S1047951126124457_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2024.01.014"},{"key":"S1047951126124457_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.10.081"},{"key":"S1047951126124457_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.01.005"},{"key":"S1047951126124457_ref14","doi-asserted-by":"publisher","DOI":"10.1067\/S0894-7317(03)00635-7"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951126124457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:46:14Z","timestamp":1791884774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951126124457\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":23,"alternative-id":["S1047951126124457"],"URL":"https:\/\/doi.org\/10.1017\/s1047951126124457","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}