{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:47:28Z","timestamp":1786999648619,"version":"build-2736575974"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T00:00:00Z","timestamp":1415318400000},"content-version":"unspecified","delay-in-days":2898,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS spectr."],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Acute administration of the partial serotonin (5-HT) agonist meta-chlorophenylpi-perazine (m-CPP), that is used also as a street drug, has been reported to induce a \u201chigh\u201d and craving response in various impulsive and sub-stance addiction disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To clarify altered 5-HT metabolism in pathological gamblers and to explore the specific role of serotonergic system in non substance addictions, we assessed behavioral (\u201chigh\u201d and \u201ccraving\u201d) and neuroendocrine (prolactin and cortisol) responses to an oral single dose of m-CPP and placebo in pathological gamblers and matched controls. Moreover, the relationship between neuroendocrine outcome and clinical severity has been assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Twenty-six pathological gamblers and 26 healthy control subjects enter a double-blind, placebo-controlled-crossed administration of orally dose m-CPP 0.5 mg\/kg. Outcome measures included prolactin and cortisol levels, gambling severity, mood, craving and \u201chigh\u201d scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pathological gamblers had significantly increased prolactin response compared to controls at 180 minutes and at 210 minutes post\u2013administration. Greater pathological gamblers severity correlated with increased neuroendocrine responsiveness to m-CCP, suggesting greater 5-HT dysregulation. Pathological gambling patients had a significantly increased \u201chigh\u201d sensation after m-CPP administration compared with control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results provide additional evidence for 5-HT disturbance in pathological gamblers and they support the hypotheses that the role of the 5-HT dysfunction related to the experience of \u201chigh\u201d might represent the path-way that leads to dyscontrolled behavior in patho-logical gamblers. Furthermore, the \u201chigh\u201d feeling induced by m-CPP in pathological subjects may represent a marker of vulnerability to both behav-ioral and substance addictions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1092852900015145","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:49:15Z","timestamp":1470098955000},"page":"956-965","source":"Crossref","is-referenced-by-count":44,"title":["Serotonin Dysfunction in Pathological Gamblers:\n                    <i>Increased Prolactin Response to Oral m-CPP Versus Placebo<\/i>"],"prefix":"10.1017","volume":"11","author":[{"given":"Stefano","family":"Pallanti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Quercioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"DeCaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hollander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"key":"S1092852900015145_ref036","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80557-7"},{"key":"S1092852900015145_ref034","doi-asserted-by":"publisher","DOI":"10.1159\/000123057"},{"key":"S1092852900015145_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91189-7"},{"key":"S1092852900015145_ref032","doi-asserted-by":"publisher","DOI":"10.1210\/endo-125-5-2664"},{"key":"S1092852900015145_ref028","volume-title":"Biol Psychiatry","author":"Pallanti"},{"key":"S1092852900015145_ref024","doi-asserted-by":"publisher","DOI":"10.1080\/13556210500350794"},{"key":"S1092852900015145_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01040-4"},{"key":"S1092852900015145_ref021","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800230026006"},{"key":"S1092852900015145_ref020","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790190025003"},{"key":"S1092852900015145_ref019","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-5-31"},{"key":"S1092852900015145_ref018","doi-asserted-by":"publisher","DOI":"10.1007\/s10899-005-5557-3"},{"key":"S1092852900015145_ref016","doi-asserted-by":"publisher","DOI":"10.1053\/scnp.2001.22929"},{"key":"S1092852900015145_ref015","doi-asserted-by":"publisher","DOI":"10.1038\/nn1578"},{"key":"S1092852900015145_ref014","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.303"},{"key":"S1092852900015145_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01593.x"},{"key":"S1092852900015145_ref009","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5544.980"},{"key":"S1092852900015145_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(95)02701-W"},{"key":"S1092852900015145_ref007","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950110058008"},{"key":"S1092852900015145_ref006","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820240085012"},{"key":"S1092852900015145_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)00199-D"},{"key":"S1092852900015145_ref003","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1176\/ajp.151.2.277","article-title":"Serotonergic sensitivity in borderline personality disorder: preliminary findings","volume":"151","author":"Hollander","year":"1994","journal-title":"Am J Psychiatry"},{"key":"S1092852900015145_ref001","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-827175"},{"key":"S1092852900015145_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(90)90660-T"},{"key":"S1092852900015145_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00182-5"},{"key":"S1092852900015145_ref031","doi-asserted-by":"publisher","DOI":"10.1159\/000124205"},{"key":"S1092852900015145_ref010","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2000"},{"key":"S1092852900015145_ref027","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820010021003"},{"key":"S1092852900015145_ref017","unstructured":"DeCaria C , Hollander E , Nora R , et al. Gambling: biological\/genetic, treatment, government, and gambling concerns: neurobiology of pathological gambling. Paper presented at: Annual Meeting of the American Psychiatric Association. May, 1997: San Diego, Calif."},{"key":"S1092852900015145_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00241-9"},{"key":"S1092852900015145_ref029","first-page":"65","article-title":"Craving for cocaine in addicted user. Role of serotonergic mechanism","volume":"6","author":"Buydens-Branchey","year":"1997","journal-title":"Am J Addict"},{"key":"S1092852900015145_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(01)00146-6"},{"key":"S1092852900015145_ref013","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.9.noc50009"},{"key":"S1092852900015145_ref035","doi-asserted-by":"publisher","DOI":"10.1159\/000123142"},{"key":"S1092852900015145_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01591.x"},{"key":"S1092852900015145_ref005","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810280099018"},{"key":"S1092852900015145_ref022","unstructured":"SPSS for Windows. Chicago, Ill: SPSS, Inc.: 1998"}],"container-title":["CNS Spectrums"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1092852900015145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T15:28:24Z","timestamp":1556810904000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1092852900015145\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S1092852900015145"],"URL":"https:\/\/doi.org\/10.1017\/s1092852900015145","relation":{},"ISSN":["1092-8529","2165-6509"],"issn-type":[{"value":"1092-8529","type":"print"},{"value":"2165-6509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}