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There are several syndromes, which are primary disturbances of clustered maladaptive aggression, most notably oppositional defiant disorder and conduct disorder. However, problems with aggression also appear in a wide range of other disturbances, such as bipolar disorder, posttraumatic stress disorder, and mood disorders. Additionally, aggression is normative, serves an adaptive purpose and can be situationally induced. These complexities need to be carefully addressed before targeting maladaptive aggression psychopharmacologically. We summarize the literature on the psychopharmacology of maladaptive aggression in youth, focusing on disorders without cognitive impairment. We delineate the subtypes of aggression which are most likely to respond to medication (reactive-affective-defensive-impulsive in their acute and chronic form) and conclude with a discussion of specific medication strategies which are supported by controlled clinical trials and clinical experience.<\/jats:p>","DOI":"10.1017\/s1092852900018514","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T03:25:45Z","timestamp":1470108345000},"page":"298-308","source":"Crossref","is-referenced-by-count":93,"title":["Psychopharmacologic Strategies for the Treatment of Aggression in Juveniles"],"prefix":"10.1017","volume":"8","author":[{"given":"Hans","family":"Steiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirti","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiki","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"key":"S1092852900018514_ref056","first-page":"128","article-title":"Predictors of response to divalproex sodium in conduct disorder","volume":"18","author":"Saxena","year":"2002","journal-title":"Scientific Proceedings of the Annual Meeting of the American Academy of Child and Adolescent Psychiatry"},{"key":"S1092852900018514_ref052","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200208000-00007"},{"key":"S1092852900018514_ref050","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v58n0102"},{"key":"S1092852900018514_ref049","doi-asserted-by":"publisher","DOI":"10.1089\/cap.1998.8.49"},{"key":"S1092852900018514_ref048","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199802000-00017"},{"key":"S1092852900018514_ref047","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2000.10.19"},{"key":"S1092852900018514_ref046","doi-asserted-by":"publisher","DOI":"10.1177\/070674370104600922"},{"key":"S1092852900018514_ref045","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200205000-00009"},{"key":"S1092852900018514_ref043","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.7.649"},{"key":"S1092852900018514_ref040","first-page":"41","article-title":"Aggression classification and treatment response","volume":"34","author":"Malone","year":"1998","journal-title":"Psychopharmacol Bull"},{"key":"S1092852900018514_ref039","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1176\/ajp.154.4.554","article-title":"Lithium treatment of conduct disorders in adolescents","volume":"154","author":"Rifkin","year":"1997","journal-title":"Am J Psychiatry"},{"key":"S1092852900018514_ref051","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199305000-00013"},{"key":"S1092852900018514_ref035","unstructured":"Klein RG . 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