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Enhanced perception of visceral stimuli (\u201cvisceral hypersensitivity\u201d) appears to be an important patho-physiological mechanism. Early IBS studies using functional brain imaging techniques suggest an alteration in central pain modulation circuits, rather than an increased sensitivity of peripheral visceral pain pathways. The frequent comorbidity with psychiatric disorders suggests the possibility of shared pathophysiological mechanisms and etiologic factors.<\/jats:p>","DOI":"10.1017\/s1092852900019830","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T04:43:12Z","timestamp":1470112992000},"page":"877-882","source":"Crossref","is-referenced-by-count":27,"title":["Pain Perception in Irritable Bowel Syndrome"],"prefix":"10.1017","volume":"10","author":[{"given":"Kirsten","family":"Tillisch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeran A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"key":"S1092852900019830_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90332-U"},{"key":"S1092852900019830_ref007","doi-asserted-by":"publisher","DOI":"10.1136\/gut.14.2.125"},{"key":"S1092852900019830_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90086-8"},{"key":"S1092852900019830_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91885-1"},{"key":"S1092852900019830_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90809-5"},{"key":"S1092852900019830_ref001","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"S1092852900019830_ref004","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.16.1773"},{"key":"S1092852900019830_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90267-8"},{"key":"S1092852900019830_ref002","volume-title":"ROME II. 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