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Many recent fibromyalgia studies have demonstrated central nervous system (CNS) pain processing abnormalities, including abnormal temporal summation of pain. In the CNS, persistent nociceptive input from peripheral tissues can lead to neuroplastic changes resulting in central sensitization and pain. This mechanism appears to represent a hallmark of fibromyalgia and many other chronic pain syndromes, including irritable bowel syndrome, temporomandibular disorder, migraine, and low back pain. Importantly, after central sensitization has been established, only minimal peripheral input is required for the maintenance of the chronic pain state. Additional factors, including pain-related negative affect and poor sleep have been shown to significantly contribute to clinical fibromyalgia pain. Better understanding of these mechanisms and their relationship to central sensitization and clinical pain will provide new approaches for the prevention and treatment of fibromyalgia and other chronic pain syndromes.<\/jats:p>","DOI":"10.1017\/s109285290002678x","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T05:01:50Z","timestamp":1470114110000},"page":"12-17","source":"Crossref","is-referenced-by-count":84,"title":["Psychophysical and Neurochemical Abnormalities of Pain Processing in 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