{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:31:43Z","timestamp":1783960303044,"version":"3.55.0"},"reference-count":59,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T00:00:00Z","timestamp":1336089600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1092852912000430_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To examine the prevalence of the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and the A2756G polymorphism of methionine synthase (MS), and their impact on antidepressant response.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852912000430_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We screened 224 subjects (52% female, mean age 39 \u00b1 11 years) with SCID-diagnosed major depressive disorder (MDD), and obtained 194 genetic samples. 49 subjects (49% female, mean age 36 \u00b1 11 years) participated in a 12-week open clinical trial of fluoxetine 20\u201360 mg\/day. Association between clinical response and C677T and A2756G polymorphisms, folate, B12, and homocysteine was examined.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852912000430_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Prevalence of the C677T and A2756G polymorphisms was consistent with previous reports (C\/C = 41%, C\/T = 47%, T\/T = 11%, A\/A = 66%, A\/G = 29%, G\/G = 4%). In the fluoxetine-treated subsample (<jats:italic>n<\/jats:italic> = 49), intent-to-treat (ITT) response rates were 47% for C\/C subjects and 46% for pooled C\/T and T\/T subjects (nonsignificant). ITT response rates were 38% for A\/A subjects and 60% for A\/G subjects (nonsignificant), with no subjects exhibiting the G\/G homozygote. Mean baseline plasma B12 was significantly lower in A\/G subjects compared to A\/A, but folate and homocysteine levels were not affected by genetic status. Plasma folate was negatively associated with treatment response.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852912000430_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>The C677T and A2756G polymorphisms did not significantly affect antidepressant response. These preliminary findings require replication in larger samples.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852912000430","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T05:29:01Z","timestamp":1336109341000},"page":"76-86","source":"Crossref","is-referenced-by-count":20,"title":["Prevalence of MTHFR C677T and MS A2756G polymorphisms in major depressive disorder, and their impact on response to fluoxetine treatment"],"prefix":"10.1017","volume":"17","author":[{"given":"David","family":"Mischoulon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Lamon-Fava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Selhub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George I.","family":"Papakostas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan V.","family":"Iosifescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert S.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Dording","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy H.","family":"Farabaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisabet J.","family":"Clain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Baer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Alpert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Nierenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Fava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,5,4]]},"reference":[{"key":"S1092852912000430_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(03)00202-X"},{"key":"S1092852912000430_ref56","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.004671"},{"key":"S1092852912000430_ref36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2004.00021.x"},{"key":"S1092852912000430_ref35","first-page":"751","article-title":"Methionine synthase polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin\/thiol metabolism","volume":"87","author":"Yates","year":"2002","journal-title":"Haematologica"},{"key":"S1092852912000430_ref55","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2011.152"},{"key":"S1092852912000430_ref52","doi-asserted-by":"crossref","unstructured":"52. 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