{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:57:26Z","timestamp":1790794646442,"version":"4.1.0"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T00:00:00Z","timestamp":1336089600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec id=\"S1092852912000491_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical features of obsessive-compulsive disorder (OCD) patients with comorbid tic disorders (TD) in a large, multicenter, clinical sample.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852912000491_abs2\" sec-type=\"general\"><jats:title>Method<\/jats:title><jats:p>A cross-sectional study was conducted that included 813 consecutive OCD outpatients from the Brazilian OCD Research Consortium and used several instruments of assessment, including the Yale-Brown Obsessive-Compulsive Scale, the Dimensional Yale-Brown Obsessive-Compulsive Scale, the Yale Global Tic Severity Scale (YGTSS), the USP Sensory Phenomena Scale, and the Structured Clinical Interview for DSM-IV Axis I Disorders.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852912000491_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The sample mean current age was 34.9 years old (SE 0.54), and the mean age at obsessive-compulsive symptoms (OCS) onset was 12.8 years old (SE 0.27). Sensory phenomena were reported by 585 individuals (72% of the sample). The general lifetime prevalence of TD was 29.0% (<jats:italic>n<\/jats:italic>= 236), with 8.9% (<jats:italic>n<\/jats:italic>= 72) presenting Tourette syndrome, 17.3% (<jats:italic>n<\/jats:italic>= 141) chronic motor tic disorder, and 2.8% (<jats:italic>n<\/jats:italic>= 23) chronic vocal tic disorder. The mean tic severity score, according to the YGTSS, was 27.2 (SE 1.4) in the OCD + TD group. Compared to OCD patients without comorbid TD, those with TD (OCD + TD group,<jats:italic>n<\/jats:italic>= 236) were more likely to be males (49.2% vs. 38.5%, p &lt; .005) and to present sensory phenomena and comorbidity with anxiety disorders in general: separation anxiety disorder, social phobia, specific phobia, generalized anxiety disorder, post-traumatic stress disorder, attention-deficit hyperactivity disorder, impulse control disorders in general, and skin picking. Also, the \u201caggressive,\u201d \u201csexual\/religious,\u201d and \u201choarding\u201d symptom dimensions were more severe in the OCD + TD group.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852912000491_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Tic-related OCD may constitute a particular subgroup of the disorder with specific phenotypical characteristics, but its neurobiological underpinnings remain to be fully disentangled.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852912000491","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T09:28:04Z","timestamp":1336123684000},"page":"87-93","source":"Crossref","is-referenced-by-count":74,"title":["Clinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study"],"prefix":"10.1017","volume":"17","author":[{"given":"Pedro Gomes","family":"de 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