{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:07:35Z","timestamp":1777446455262,"version":"3.51.4"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>ISSUE:Reports of rapid-onset but short-duration antidepressant effects in patients with treatment-resistant mood disorders after intravenous administration of ketamine have prompted efforts to find an agent with ketamine's properties that can be administered orally in repeated doses in order to sustain that action. One candidate for this is dextromethorphan, and here the pharmacologic mechanism of action is compared and contrasted with that of ketamine.<\/jats:p>","DOI":"10.1017\/s109285291300062x","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T10:04:30Z","timestamp":1379671470000},"page":"225-227","source":"Crossref","is-referenced-by-count":15,"title":["Mechanism of action of dextromethorphan\/quinidine: comparison with ketamine"],"prefix":"10.1017","volume":"18","author":[{"given":"Stephen M.","family":"Stahl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"key":"S109285291300062X_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.338"},{"key":"S109285291300062X_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711000927"},{"key":"S109285291300062X_ref5","unstructured":"Roth BL . Ki determinations, receptor binding profiles, agonist and\/or antagonist functional data, HERG data, MDR1 data, etc. as appropriate was generously provided by the National Institute of Mental Health's Psychoactive Drug Screening Program (PDSP), Contract # HHSN-271-2008-00025-C (NIMH PDSP). The NIMH PDSP is directed by Bryan L. Roth MD, PhD, at the University of North Carolina at Chapel Hill and Project Officer Jamie Driscol at NIMH, Bethesda, MD, USA. For experimental details, please refer to the PDSP Web site: http:\/\/pdsp.med.unc.edu"},{"key":"S109285291300062X_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S109285291300045X"},{"key":"S109285291300062X_ref1","unstructured":"Prescribing information, Nuedexta Package insert, 2013."},{"key":"S109285291300062X_ref9","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2009.034.02.1336115"},{"key":"S109285291300062X_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22093"},{"key":"S109285291300062X_ref10","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n1101"},{"key":"S109285291300062X_ref4","volume-title":"Stahl's Essential Psychopharmacology","author":"Stahl","year":"2013"},{"key":"S109285291300062X_ref3","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142042.50528.2F"}],"container-title":["CNS Spectrums"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S109285291300062X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T19:32:45Z","timestamp":1556047965000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S109285291300062X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,20]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S109285291300062X"],"URL":"https:\/\/doi.org\/10.1017\/s109285291300062x","relation":{},"ISSN":["1092-8529","2165-6509"],"issn-type":[{"value":"1092-8529","type":"print"},{"value":"2165-6509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,20]]}}}