{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:02:34Z","timestamp":1790265754833,"version":"4.1.0"},"reference-count":66,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec id=\"S109285291400011X_abs1\" sec-type=\"intro\"><jats:title>Introduction<\/jats:title><jats:p>Pituitary enlargement has been reported in individuals with schizophrenic psychosis or an at-risk mental state for psychosis (ARMS). In a previous study, our group could show pituitary volume increase in first episode and ARMS patients with later transition to psychosis (ARMS-T). However, there are no longitudinal studies on this issue so far. We therefore examined longitudinally whether transition to psychosis would be accompanied by a further increase of pituitary volume in antipsychotic-na\u00efve ARMS patients.<\/jats:p><\/jats:sec><jats:sec id=\"S109285291400011X_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Magnetic resonance imaging (MRI) data were acquired from 23 antipsychotic-na\u00efve individuals with an ARMS. Ten subjects developed psychosis (ARMS-T) and 13 did not (ARMS-NT). ARMS-T were re-scanned after the onset of psychosis, and ARMS-NT were re-scanned at the end of the study period.<\/jats:p><\/jats:sec><jats:sec id=\"S109285291400011X_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>There was no significant difference of the pituitary volume between ARMS-T and ARMS-NT in our sample, and there were no significant pituitary volume changes over time.<\/jats:p><\/jats:sec><jats:sec id=\"S109285291400011X_abs4\" sec-type=\"discussion\"><jats:title>Discussion<\/jats:title><jats:p>Longitudinally, we could not detect any further volumetric changes in the pituitary volume with transition to psychosis.<\/jats:p><\/jats:sec><jats:sec id=\"S109285291400011X_abs5\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>This, together with the result of our previous study, could indicate that the perceived level of stress in ARMS patients is constantly high from very early 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