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Such treatment strategies include both antipsychotic polypharmacy (simultaneous use of 2 antipsychotics) and high-dose antipsychotic monotherapy. Here we discuss the hypothesized neurobiological substrates of various types of violence and aggression, as well as providing arguments for the use of antipsychotic polypharmacy and high-dose monotherapy to target dysfunctional neurocircuitry in the subpopulation of patients that is treatment-resistant, violent, and aggressive. In this review, we focus primarily on the data supporting the use of second-generation, atypical antipsychotics both at high doses and in combination with other antipsychotics.<\/jats:p>","DOI":"10.1017\/s1092852914000388","type":"journal-article","created":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T14:51:49Z","timestamp":1408027909000},"page":"439-448","source":"Crossref","is-referenced-by-count":34,"title":["Treating the violent patient with psychosis or impulsivity utilizing antipsychotic polypharmacy and high-dose monotherapy"],"prefix":"10.1017","volume":"19","author":[{"given":"Debbi A.","family":"Morrissette","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,8,14]]},"reference":[{"key":"S1092852914000388_ref80","doi-asserted-by":"publisher","DOI":"10.1586\/ern.12.7"},{"key":"S1092852914000388_ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.02.010"},{"key":"S1092852914000388_ref71","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1884-9"},{"key":"S1092852914000388_ref66","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145703004012"},{"key":"S1092852914000388_ref69","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.11081259"},{"key":"S1092852914000388_ref81","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31825244f6"},{"key":"S1092852914000388_ref75","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710000490"},{"key":"S1092852914000388_ref55","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.002022012"},{"key":"S1092852914000388_ref33","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1176\/ajp.156.4.544","article-title":"Predictors of treatment response from a first episode of schizophrenia or schizoaffective disorder","volume":"156","author":"Robinson","year":"1999","journal-title":"Am J Psychiatry"},{"key":"S1092852914000388_ref61","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.2e011.x"},{"key":"S1092852914000388_ref35","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852912000739"},{"key":"S1092852914000388_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.03.015"},{"key":"S1092852914000388_ref46","doi-asserted-by":"publisher","DOI":"10.1177\/0004867413488221"},{"key":"S1092852914000388_ref39","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746050-00001"},{"key":"S1092852914000388_ref38","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2013.0007"},{"key":"S1092852914000388_ref58","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10060908"},{"key":"S1092852914000388_ref51","doi-asserted-by":"publisher","DOI":"10.1177\/0269881113477709"},{"key":"S1092852914000388_ref44","first-page":"640","article-title":"Long-term high-dose neuroleptic treatment: who gets it and why?","volume":"44","author":"Krakowski","year":"1993","journal-title":"Hosp Community Psychiatry"},{"key":"S1092852914000388_ref34","volume-title":"Stahl's Essential Psychopharmacology","author":"Stahl","year":"2008"},{"key":"S1092852914000388_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2012.01841.x"},{"key":"S1092852914000388_ref60","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145704004146"},{"key":"S1092852914000388_ref21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000120"},{"key":"S1092852914000388_ref25","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181855cd6"},{"key":"S1092852914000388_ref62","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0201"},{"key":"S1092852914000388_ref36","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-007-5805-6","volume-title":"Polypharmacy in Psychiatric Practice, Volume I: Multiple Medication Use Strategies","author":"Ritsner","year":"2013"},{"key":"S1092852914000388_ref12","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07111774"},{"key":"S1092852914000388_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2008.01797.x"},{"key":"S1092852914000388_ref76","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0505"},{"key":"S1092852914000388_ref59","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043456070"},{"key":"S1092852914000388_ref37","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-5805-6"},{"key":"S1092852914000388_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.02.032"},{"key":"S1092852914000388_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/S146114571100201X"},{"key":"S1092852914000388_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s13353-011-0069-6"},{"key":"S1092852914000388_ref4","unstructured":"Warburton K . 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