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This review article encompasses the clinical phenomenology of motor and vocal tics and associated sensory experiences (premonitory urges), as well as the behavioral spectrum of the most common comorbidities, including obsessive-compulsive disorder, attention-deficit and hyperactivity disorder, affective symptoms, and impulsivity. Knowledge of the contributions of both tics and behavioral problems to patients\u2019 health-related quality of life across the lifespan should assist treating clinicians in formulating a targeted management plan. Although the exact pathophysiology of Gilles de la Tourette syndrome remains elusive, research into therapeutic interventions has expanded the range of available interventions across multiple domains. A thorough understanding of the neurology and psychiatry of this condition is of key importance to meet the needs of this patient population, from the formulation of an accurate diagnosis to the implementation of effective treatment strategies.<\/jats:p>","DOI":"10.1017\/s1092852918000834","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T06:52:37Z","timestamp":1526885557000},"page":"213-218","source":"Crossref","is-referenced-by-count":51,"title":["Gilles de la Tourette syndrome as a paradigmatic neuropsychiatric disorder"],"prefix":"10.1017","volume":"23","author":[{"given":"Andrea 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