{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:26:32Z","timestamp":1777623992531,"version":"3.51.4"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec id=\"S1092852918001700_sec1\" sec-type=\"other\"><jats:title>Objective.<\/jats:title><jats:p>To investigate if sleep disturbances may affect treatment outcomes of patients with panic disorder (PD).<\/jats:p><\/jats:sec><jats:sec id=\"S1092852918001700_sec2\" sec-type=\"methods\"><jats:title>Methods.<\/jats:title><jats:p>Eighty-five PD outpatients with no Axis I comorbidity for mood disorders completed a baseline assessment (T1) and were evaluated after 3 (T2), 6 (T3) and 12 months (T4), with the Panic Disorder Severity Scale (PDSS) total score as outcome measure during a 12-month naturalistic follow-up. Patients were assessed with the Mood Spectrum Self-Report (MOODS-SR, Lifetime Version), and the PDSS.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852918001700_sec3\" sec-type=\"results\"><jats:title>Results.<\/jats:title><jats:p>Forty-three patients (50.5%) met criteria for remission (PDSS&lt;5) and 42 (49.5%) for no remission. In a logistic regression model with<jats:italic>remission<\/jats:italic>as the dependent variable, MOODS-SR<jats:italic>sleep disturbances<\/jats:italic>was the only determinant for a lower likelihood of PD remission. The items accounting for this result were the following:<jats:italic>Repeated difficulty falling asleep<\/jats:italic>(chi-square = 4.4; df = 1;<jats:italic>p<\/jats:italic>= 0.036), and<jats:italic>Repeatedly waking up in the middle of the night<\/jats:italic>(chi-square = 5.2; df = 1;<jats:italic>p<\/jats:italic>= 0.022).<\/jats:p><\/jats:sec><jats:sec id=\"S1092852918001700_sec4\" sec-type=\"conclusions\"><jats:title>Conclusion.<\/jats:title><jats:p>Lifetime sleep disturbances would represent a cue of mood spectrum (in absence of overt affective comorbidity) that may impair remission in PD.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852918001700","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T12:29:40Z","timestamp":1554985780000},"page":"32-37","source":"Crossref","is-referenced-by-count":4,"title":["Can sleep disturbance be a cue of mood spectrum comorbidity? 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