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Multiple linear regression analysis and visual inspection of plots were performed.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920001091_sec3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement\/hostility the second, depression the third, and neurocognitive decline the last stage.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920001091_sec4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct \u201ccores\u201d of schizophrenia, the \u201cPositive\u201d and the \u201cNegative,\u201d while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852920001091","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T06:27:23Z","timestamp":1586932043000},"page":"290-298","source":"Crossref","is-referenced-by-count":7,"title":["Modeling psychological function in patients with schizophrenia with the PANSS: an international multi-center study"],"prefix":"10.1017","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5503-0811","authenticated-orcid":false,"given":"Konstantinos 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