{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:34:32Z","timestamp":1784673272472,"version":"3.55.0"},"reference-count":57,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1092852920001777_sec91\"><jats:title>Background<\/jats:title><jats:p>Bipolar disorder (BD) is linked to circadian rhythm disruptions resulting in aberrant motor activity patterns. We aimed to explore whether motor activity alone, as assessed by longitudinal actigraphy, can be used to classify accurately BD patients and healthy controls (HCs) into their respective groups.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920001777_sec92\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Ninety-day actigraphy records from 25 interepisode BD patients (ie, Montgomery\u2013Asberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS)\u00a0&lt;\u00a015) and 25 sex- and age-matched HCs were used in order to identify latent actigraphic biomarkers capable of discriminating between BD patients and HCs. Mean values and time variations of a set of standard actigraphy features were analyzed and further validated using the random forest classifier.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920001777_sec93\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Using all actigraphy features, this method correctly assigned 88% (sensitivity\u00a0=\u00a085%, specificity\u00a0=\u00a091%) of BD patients and HCs to their respective group. The classification success may be confounded by differences in employment between BD patients and HCs. When motor activity features resistant to the employment status were used (the strongest feature being time variation of intradaily variability, Cohen\u2019s <jats:italic>d<\/jats:italic>\u00a0=\u00a01.33), 79% of the subjects (sensitivity\u00a0=\u00a076%, specificity\u00a0=\u00a081%) were correctly classified.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920001777_sec94\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>A machine-learning actigraphy-based model was capable of distinguishing between interepisode BD patients and HCs solely on the basis of motor activity. The classification remained valid even when features influenced by employment status were omitted. The findings suggest that temporal variability of actigraphic parameters may provide discriminative power for differentiating between BD patients and HCs while being less affected by employment status.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852920001777","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T06:48:34Z","timestamp":1599202114000},"page":"82-92","source":"Crossref","is-referenced-by-count":22,"title":["Motor activity patterns can distinguish between interepisode bipolar disorder patients and healthy controls"],"prefix":"10.1017","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-8538","authenticated-orcid":false,"given":"Jakub","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Bak\u0161tein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Koleni\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Vostatek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph U.","family":"Correll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nov\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"\u0160paniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"S1092852920001777_r55","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.04.020"},{"key":"S1092852920001777_r44","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5646848"},{"key":"S1092852920001777_r10","first-page":"183","article-title":"Circadian biomarkers, circadian genes and bipolar disorders","volume":"105","author":"Milhiet","year":"2011","journal-title":"J Physiol"},{"key":"S1092852920001777_r37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00761.x"},{"key":"S1092852920001777_r43","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-013-0438-7"},{"key":"S1092852920001777_r30","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.06.006"},{"key":"S1092852920001777_r5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.01.012"},{"key":"S1092852920001777_r16","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.1.50"},{"key":"S1092852920001777_r34","volume-title":"Diagnostic and Statistical Manual of Mental Disorders\u00a0: DSM-5","year":"2013"},{"key":"S1092852920001777_r47","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2007.07.005"},{"key":"S1092852920001777_r45","first-page":"65","article-title":"Board of the Foundation of the Scandinavian Journal of Statistics. 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