{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:09:46Z","timestamp":1769605786882,"version":"3.49.0"},"reference-count":74,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1092852920001820_sec1\"><jats:title>Objective<\/jats:title><jats:p>To provide evidence to the link between serotonin (5-HT), energy metabolism, and the human obese phenotype, the present study investigated the binding and function of the platelet 5-HT transporter (SERT), in relation to circulating insulin, leptin, and glycolipid metabolic parameters.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920001820_sec2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Seventy-four drug-free subjects were recruited on the basis of divergent body mass index (BMIs) (16.5-54.8\u00a0Kg\/m<jats:sup>2<\/jats:sup>). All subjects were tested for their blood glycolipid profile together with platelet [<jats:sup>3<\/jats:sup>H]-paroxetine ([<jats:sup>3<\/jats:sup>H]-Par) binding and [<jats:sup>3<\/jats:sup>H]-5-HT reuptake measurements from April 1st to June 30th, 2019.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920001820_sec3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The [<jats:sup>3<\/jats:sup>H]-Par <jats:italic>B<\/jats:italic><jats:sub>max<\/jats:sub> (fmol\/mg proteins) was progressively reduced with increasing BMIs (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), without changes in affinity. Moreover, <jats:italic>B<\/jats:italic><jats:sub>max<\/jats:sub> was negatively correlated with BMI, waist\/hip circumferences (W\/HC), triglycerides (TD), glucose, insulin, and leptin, while positively with high-density lipoprotein (HDL) cholesterol (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). The reduction of 5-HT uptake rate (<jats:italic>V<\/jats:italic><jats:sub>max<\/jats:sub>, pmol\/min\/10<jats:sup>9<\/jats:sup> platelets) among BMI groups was not statistically significant, but <jats:italic>V<\/jats:italic><jats:sub>max<\/jats:sub> negatively correlated with leptin and uptake affinity values (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Besides, [<jats:sup>3<\/jats:sup>H]-Par affinity values positively correlated with glycemia and TD, while [<jats:sup>3<\/jats:sup>H]-5-HT reuptake affinity with glycemia only (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Finally, these correlations were specific of obese subjects, while, from multiple linear-regression analysis conducted on all subjects, insulin (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006) resulting negatively related to <jats:italic>B<\/jats:italic><jats:sub>max<\/jats:sub> independently from BMI.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920001820_sec4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Present findings suggest the presence of a possible alteration of insulin\/5-HT\/leptin axis in obesity, differentially impinging the density, function, and\/or affinity of the platelet SERT, as a result of complex appetite\/reward-related interactions between the brain, gut, pancreatic islets, and adipose tissue. Furthermore, they support the foremost cooperation of peptides and 5-HT in maintaining energy homeostasis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852920001820","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T05:19:57Z","timestamp":1600060797000},"page":"99-108","source":"Crossref","is-referenced-by-count":11,"title":["The complex interactions among serotonin, insulin, leptin, and glycolipid metabolic parameters in human 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