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We found no cross-sectional studies in which participants received the index test (MoCA) and a reference standard diagnostic assessment composed of an extensive neuropsychological battery. The publication period ranged from 2010 to 2020.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920001868_sec3\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>In patients with HD, the MoCA provides information about disturbances in general cognitive function. Even if the MoCA demonstrated good sensitivity and specificity when used at the recommended threshold score of 26, further cross-sectional studies are required to examine the optimum cutoff score for detecting cognitive impairments in patients with HD. 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