{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:58:12Z","timestamp":1788188292652,"version":"build-2803163510"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1092852920002102_sec1\"><jats:title>Background<\/jats:title><jats:p>Higher body mass index (BMI) has been found to predict greater antidepressant response to intravenous (IV) ketamine treatment. We evaluated the association between BMI and response to repeat-dose IV ketamine in patients with treatment-resistant depression (TRD).<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920002102_sec2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Adults (N\u00a0=\u00a0230) with TRD received four infusions of IV ketamine at a community-based clinic. Changes in symptoms of depression (ie, Quick Inventory for Depressive Symptomatology-Self-Report 16; QIDS-SR<jats:sub>16<\/jats:sub>), suicidal ideation (SI; ie, QIDS-SR<jats:sub>16<\/jats:sub> SI item), anxiety (ie, Generalized Anxiety Disorder-7 Scale), anhedonic severity (ie, Snaith\u2013Hamilton Pleasure Scale), and functioning (ie, Sheehan Disability Scale) following infusions were evaluated. Participants were stratified by BMI as normal (18.0-24.9\u00a0kg\/m<jats:sup>2<\/jats:sup>; n\u00a0=\u00a072), overweight (25-29.9\u00a0kg\/m<jats:sup>2<\/jats:sup>; n\u00a0=\u00a076), obese I (30-34.9\u00a0kg\/m<jats:sup>2<\/jats:sup>; n\u00a0=\u00a047), or obese II (\u226535.0\u00a0kg\/m<jats:sup>2<\/jats:sup>; n\u00a0=\u00a035).<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920002102_sec3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Similar antidepressant effects with repeat-dose ketamine were reported between BMI groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.261). In addition, categorical partial response (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.149), response (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.526), and remission (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.232) rates were similar between the four BMI groups.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852920002102_sec4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>The findings are limited by the observational, open-label design of this retrospective analysis. Pretreatment BMI did not predict response to IV ketamine, which was effective regardless of BMI.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852920002102","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T04:25:15Z","timestamp":1606969515000},"page":"322-330","source":"Crossref","is-referenced-by-count":19,"title":["Does body mass index predict response to intravenous ketamine treatment in adults with major depressive and bipolar disorder? 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