{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:52:06Z","timestamp":1789469526076,"version":"build-2803163510"},"reference-count":116,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Cognitive impairment is common in bipolar disorder and is emerging as a therapeutic target to enhance quality of life and function. A systematic search was conducted on PubMed, PsycInfo, Cochrane, clinicaltrials.gov, and Embase databases for blinded or open-label randomized controlled trials evaluating the pro-cognitive effects of pharmacological, neurostimulation, or psychological interventions for bipolar disorder. Twenty-two trials were identified, evaluating a total of 16 different pro-cognitive interventions. The methodological quality of the identified trials were assessed using the Cochrane Risk of Bias tool. Currently, no intervention (i.e., pharmacologic, neurostimulation, cognitive remediation) has demonstrated robust and independent pro-cognitive effects in adults with bipolar disorder. Findings are preliminary and methodological limitations limit the interpretation of results. Methodological considerations including, but not limited to, the enrichment with populations with pre-treatment cognitive impairment, as well as the inclusion of individuals who are in remission are encouraged. Future trials may also consider targeting interventions to specific cognitive subgroups and the use of biomarkers of cognitive function.<\/jats:p>","DOI":"10.1017\/s1092852921000092","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T08:17:17Z","timestamp":1611821837000},"page":"1-22","source":"Crossref","is-referenced-by-count":25,"title":["Management of cognitive impairment in bipolar disorder: a systematic review of randomized controlled trials"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0077-2057","authenticated-orcid":false,"given":"Jocelyn K.","family":"Tamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle P.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lui M. W.","family":"Leanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Nuo","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Rosenblat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Mansur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yena","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle S.","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Teopiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Nasri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4733-2523","authenticated-orcid":false,"given":"Roger S.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"S1092852921000092_r108","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2010.11.2228"},{"key":"S1092852921000092_r90","doi-asserted-by":"publisher","DOI":"10.26226\/morressier.5785edc9d462b80296c99855"},{"key":"S1092852921000092_r91","doi-asserted-by":"publisher","DOI":"10.1038\/nn1707"},{"key":"S1092852921000092_r65","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpsm.2018.09.002"},{"key":"S1092852921000092_r110","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301534"},{"key":"S1092852921000092_r52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-2406.2003.00059.x"},{"key":"S1092852921000092_r72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027265"},{"key":"S1092852921000092_r33","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.115.173930"},{"key":"S1092852921000092_r11","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291718003008"},{"key":"S1092852921000092_r106","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4048"},{"key":"S1092852921000092_r26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.05.029"},{"key":"S1092852921000092_r66","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200822010-00002"},{"key":"S1092852921000092_r85","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"S1092852921000092_r86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2009.00090.x"},{"key":"S1092852921000092_r22","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.17m11476"},{"key":"S1092852921000092_r113","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000546"},{"key":"S1092852921000092_r41","first-page":"1","article-title":"Effect of action-based cognitive remediation on cognitive impairment in patients with remitted bipolar disorder: a randomized controlled trial","author":"Ott","year":"2020","journal-title":"Bipolar Disord"},{"key":"S1092852921000092_r12","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00028-2"},{"key":"S1092852921000092_r29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300471"},{"key":"S1092852921000092_r74","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0209"},{"key":"S1092852921000092_r104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00733.x"},{"key":"S1092852921000092_r67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211427898"},{"key":"S1092852921000092_r98","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.03.016"},{"key":"S1092852921000092_r70","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706122"},{"key":"S1092852921000092_r27","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12006"},{"key":"S1092852921000092_r48","doi-asserted-by":"publisher","DOI":"10.1186\/1550-2783-9-33"},{"key":"S1092852921000092_r60","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.104420"},{"key":"S1092852921000092_r107","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2013-1299"},{"key":"S1092852921000092_r111","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.007054"},{"key":"S1092852921000092_r56","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.01.004"},{"key":"S1092852921000092_r64","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.3.564"},{"key":"S1092852921000092_r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.04.022"},{"key":"S1092852921000092_r25","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08839"},{"key":"S1092852921000092_r49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01040.x"},{"key":"S1092852921000092_r97","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.08.018"},{"key":"S1092852921000092_r76","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2019-0344"},{"key":"S1092852921000092_r80","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2017.07.395"},{"key":"S1092852921000092_r40","first-page":"1","article-title":"Cognitive remediation therapy for patients with bipolar disorder: a randomised proof-of-concept trial","author":"Strawbridge","year":"2020","journal-title":"Bipolar Disord"},{"key":"S1092852921000092_r34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2012.02392.x"},{"key":"S1092852921000092_r42","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14cs09399"},{"key":"S1092852921000092_r102","article-title":"An fMRI study in patients with active mania using verbal n-back test","volume":"33","author":"Gupta","year":"2016","journal-title":"Eur Psychiatry"},{"key":"S1092852921000092_r20","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jad.2018.12.102","article-title":"High-frequency repetitive transcranial magnetic stimulation (rTMS) improves neurocognitive function in bipolar disorder","volume":"246","author":"Lin-Lin","year":"2019","journal-title":"J Affect Disord"},{"key":"S1092852921000092_r99","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15041-1"},{"key":"S1092852921000092_r5","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12595"},{"key":"S1092852921000092_r2","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-016-0066-0"},{"key":"S1092852921000092_r78","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2008.00651.x"},{"key":"S1092852921000092_r112","first-page":"2775","article-title":"Effect of lamotrigine on cognitive function and serum inflammatory factors in patients with depression of recurrent bipolar disorder","volume":"31","author":"Shi","year":"2018","journal-title":"Pak J Pharm Sci"},{"key":"S1092852921000092_r14","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12148"},{"key":"S1092852921000092_r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.08.004"},{"key":"S1092852921000092_r31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.11.029"},{"key":"S1092852921000092_r23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.11.037"},{"key":"S1092852921000092_r10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01503.x"},{"key":"S1092852921000092_r82","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.03.052"},{"key":"S1092852921000092_r35","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m07299"},{"key":"S1092852921000092_r87","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12534"},{"key":"S1092852921000092_r51","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.01.016"},{"key":"S1092852921000092_r75","doi-asserted-by":"publisher","DOI":"10.2174\/1745017901107010112"},{"key":"S1092852921000092_r105","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2301"},{"key":"S1092852921000092_r19","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12784"},{"key":"S1092852921000092_r83","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.4.s1.41.x"},{"key":"S1092852921000092_r81","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1077(199806)13:4<271::AID-HUP995>3.0.CO;2-G"},{"key":"S1092852921000092_r43","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.08.011"},{"key":"S1092852921000092_r96","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00546"},{"key":"S1092852921000092_r94","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.16m11329"},{"key":"S1092852921000092_r95","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.1736"},{"key":"S1092852921000092_r73","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10060855"},{"key":"S1092852921000092_r62","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.05.027"},{"key":"S1092852921000092_r89","doi-asserted-by":"publisher","DOI":"10.1037\/a0020859"},{"key":"S1092852921000092_r46","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2013.00863"},{"key":"S1092852921000092_r58","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-019-00641-3"},{"key":"S1092852921000092_r15","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12341"},{"key":"S1092852921000092_r4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0193-953X(03)00106-0","article-title":"Cognitive and neurological impairment in mood disorders","volume":"27","author":"Cherie","year":"2004","journal-title":"Psychiatr Clin North Am"},{"key":"S1092852921000092_r61","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0189"},{"key":"S1092852921000092_r115","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31544-0"},{"key":"S1092852921000092_r79","doi-asserted-by":"publisher","DOI":"10.1002\/da.20027"},{"key":"S1092852921000092_r116","doi-asserted-by":"publisher","DOI":"10.1002\/da.22063"},{"key":"S1092852921000092_r7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.009"},{"key":"S1092852921000092_r77","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.05.021"},{"key":"S1092852921000092_r36","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119826602"},{"key":"S1092852921000092_r57","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.08.003"},{"key":"S1092852921000092_r69","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.09.011"},{"key":"S1092852921000092_r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.02.016"},{"key":"S1092852921000092_r28","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181a497d7"},{"key":"S1092852921000092_r109","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13r08560"},{"key":"S1092852921000092_r84","doi-asserted-by":"publisher","DOI":"10.1016\/j.chc.2018.07.008"},{"key":"S1092852921000092_r44","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12848"},{"key":"S1092852921000092_r6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2010.00768.x"},{"key":"S1092852921000092_r18","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(14)70003-5"},{"key":"S1092852921000092_r59","doi-asserted-by":"publisher","DOI":"10.1080\/09513590601005946"},{"key":"S1092852921000092_r1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-019-00688-2"},{"key":"S1092852921000092_r71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112209109"},{"key":"S1092852921000092_r92","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m07471"},{"key":"S1092852921000092_r93","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1176\/ajp.150.9.1355","article-title":"Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery","volume":"150","author":"Goldberg","year":"1993","journal-title":"Am J Psychiatry"},{"key":"S1092852921000092_r55","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.167346"},{"key":"S1092852921000092_r3","first-page":"3111","article-title":"Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses","volume":"11","author":"Bortolato","year":"2015","journal-title":"Neuropsychiatr Dis Treat"},{"key":"S1092852921000092_r38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.09.056"},{"key":"S1092852921000092_r32","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30046-9"},{"key":"S1092852921000092_r47","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.17m11476"},{"key":"S1092852921000092_r54","unstructured":"54. United States Food and Drug Administration. LATUDA (lurasidone hydrochloride) tablets\u2014FDA. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/200603s26s27lbl.pdf."},{"key":"S1092852921000092_r88","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.12.105"},{"key":"S1092852921000092_r100","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2001.030302.x"},{"key":"S1092852921000092_r30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127955"},{"key":"S1092852921000092_r114","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.16m10744"},{"key":"S1092852921000092_r16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2012.01011.x"},{"key":"S1092852921000092_r45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"S1092852921000092_r53","unstructured":"53. Government of Canada, Health Canada, Health Products, Branch F. Search page\u2014drug and health product register. Published October 23, 2014. Accessed November 8, 2020. https:\/\/hpr-rps.hres.ca\/reg-content\/regulatory-decision-summary-detail.php?lang=en&linkID=RDS00369."},{"key":"S1092852921000092_r8","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12463"},{"key":"S1092852921000092_r63","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.04.022"},{"key":"S1092852921000092_r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.09.011"},{"key":"S1092852921000092_r24","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08413"},{"key":"S1092852921000092_r103","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00583"},{"key":"S1092852921000092_r68","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02136.x"},{"key":"S1092852921000092_r101","first-page":"S232","article-title":"A functional neuroimaging investigation of brain pathways involved in patients during active mania using stroop colour word test","volume":"33","author":"Gupta","year":"2016","journal-title":"Eur Psychiatry"},{"key":"S1092852921000092_r37","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12070971"},{"key":"S1092852921000092_r39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.05.073"},{"key":"S1092852921000092_r50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2010.10.005"}],"container-title":["CNS Spectrums"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1092852921000092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T07:51:49Z","timestamp":1615535509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1092852921000092\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,28]]},"references-count":116,"alternative-id":["S1092852921000092"],"URL":"https:\/\/doi.org\/10.1017\/s1092852921000092","relation":{},"ISSN":["1092-8529","2165-6509"],"issn-type":[{"value":"1092-8529","type":"print"},{"value":"2165-6509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,28]]}}}