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The adjunctive use of nutraceuticals with potential neuromodulatory effects on underpinning pathways such as the glutamatergic and serotonergic systems is one novel approach.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852921000638_sec2\"><jats:title>Objective<\/jats:title><jats:p>To assess the effectiveness and safety of a purpose-formulated combination of nutraceuticals in treating OCD:<jats:italic>N<\/jats:italic>-acetyl cysteine, L-theanine, zinc, magnesium, pyridoxal-5\u2032 phosphate, and selenium.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852921000638_sec3\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A 20-week open label proof-of-concept study was undertaken involving 28 participants with treatment-resistant DSM-5-diagnosed OCD, during 2017 to 2020. The primary outcome measure was the Yale-Brown Obsessive\u2013Compulsive Scale (YBOCS), administered every 4\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852921000638_sec4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>An intention-to-treat analysis revealed an estimated mean reduction across time (baseline to week-20) on the YBOCS total score of \u22127.13 (95% confidence interval\u00a0=\u00a0\u22129.24, \u22125.01), with a mean reduction of \u22121.21 points per post-baseline visit (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.001). At 20-weeks, 23% of the participants were considered \u201cresponders\u201d (YBOCS \u226535% reduction and \u201cvery much\u201d or \u201cmuch improved\u201d on the Clinical Global Impression-Improvement scale). Statistically significant improvements were also revealed on all secondary outcomes (eg, mood, anxiety, and quality of life). Notably, treatment response on OCD outcome scales (eg, YBOCS) was greatest in those with lower baseline symptom levels, while response was limited in those with relatively more severe OCD.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852921000638_sec5\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>While this pilot study lacks placebo-control, the significant time effect in this treatment-resistant OCD population is encouraging and suggests potential utility especially for those with lower symptom levels. Our findings need to be confirmed or refuted via a follow-up placebo-controlled study.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852921000638","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T04:09:52Z","timestamp":1624248592000},"page":"588-597","source":"Crossref","is-referenced-by-count":9,"title":["Treatment of refractory obsessive\u2013compulsive disorder with nutraceuticals (TRON): a 20-week, open label pilot study"],"prefix":"10.1017","volume":"27","author":[{"given":"Jerome","family":"Sarris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J.","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5276-5249","authenticated-orcid":false,"given":"Lachlan","family":"Cribb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Blair-West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Castle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia M.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Camfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlasios","family":"Brakoulias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Bousman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Dowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Ee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenifer","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneel","family":"Chamoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Boschen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee H.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"S1092852921000638_r24","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2011.11.027"},{"key":"S1092852921000638_r41","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291704003873"},{"key":"S1092852921000638_r43","unstructured":"43. 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