{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T16:52:42Z","timestamp":1794243162037,"version":"4.9.0"},"reference-count":118,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is well established that migraine is a multifactorial disorder. A deep understanding of migraine should be based upon both the underlying traits and the current states affected by different physiological, psychological, and environmental factors. At this point, there is no framework fully meeting these criteria. Here, we describe a broader view of the migraine disorder defined as a dysfunctional brain state and trait interaction. In this model, we consider events that may enhance or diminish migraine responsivity based on an individual\u2019s trait and state. This could provide an expanded view for considering how migraine attacks are sometimes precipitated by \u201ctriggers\u201d and sometimes not, how these factors only lead to migraine attacks in migraine patients, or how individuals with an increased risk for migraine do not show any symptoms at all. Summarizing recent studies and evidence that support the concept of migraine as a brain state\u2013trait interaction can also contribute to improving patient care by highlighting the importance of precision medicine and applying measures that are able to capture how different traits and states work together to determine migraine.<\/jats:p>","DOI":"10.1017\/s109285292100064x","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T08:09:53Z","timestamp":1624262993000},"page":"561-569","source":"Crossref","is-referenced-by-count":6,"title":["Migraine: interactions between brain\u2019s trait and state"],"prefix":"10.1017","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4087-5373","authenticated-orcid":false,"given":"Edina","family":"Szabo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthana Deepti","family":"Karunakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine B.","family":"Sieberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Elman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Burstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Borsook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"S109285292100064X_r80","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6185(01)00060-3"},{"key":"S109285292100064X_r30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01425.x"},{"key":"S109285292100064X_r18","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8434-y"},{"key":"S109285292100064X_r11","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/205985"},{"key":"S109285292100064X_r117","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072827"},{"key":"S109285292100064X_r26","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b8791a"},{"key":"S109285292100064X_r29","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416678624"},{"key":"S109285292100064X_r114","doi-asserted-by":"publisher","DOI":"10.1177\/2049463715578291"},{"key":"S109285292100064X_r91","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-019-0826-5"},{"key":"S109285292100064X_r111","unstructured":"111. National Institutes of Health (NIH). NIH-funded genome centers to accelerate precision medicine discoveries. Published September 25, 2018. https:\/\/www.nih.gov\/news-events\/news-releases\/nih-funded-genome-centers-accelerate-precision-medicine-discoveries. Accessed December 1, 2020."},{"key":"S109285292100064X_r82","doi-asserted-by":"publisher","DOI":"10.1080\/02699931.2014.922460"},{"key":"S109285292100064X_r103","doi-asserted-by":"publisher","DOI":"10.1111\/head.12004"},{"key":"S109285292100064X_r27","doi-asserted-by":"publisher","DOI":"10.1111\/head.12999"},{"key":"S109285292100064X_r15","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001531"},{"key":"S109285292100064X_r21","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1017-9"},{"key":"S109285292100064X_r74","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13161"},{"key":"S109285292100064X_r36","first-page":"209","article-title":"Presence of symptoms of dysautonomia in patients with migraine with aura and migraine without aura: a retrospective study","volume":"2","author":"Ozer","year":"2018","journal-title":"Eurasian J Med Oncol"},{"key":"S109285292100064X_r35","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2018.1414601"},{"key":"S109285292100064X_r53","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-021-00240-5"},{"key":"S109285292100064X_r97","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2011.573883"},{"key":"S109285292100064X_r101","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.01.001"},{"key":"S109285292100064X_r24","doi-asserted-by":"publisher","DOI":"10.1111\/head.12536"},{"key":"S109285292100064X_r10","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0675-0"},{"key":"S109285292100064X_r17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0373-15.2015"},{"key":"S109285292100064X_r51","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32832d93dd"},{"key":"S109285292100064X_r62","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-012-0424-y"},{"key":"S109285292100064X_r107","first-page":"1417","article-title":"A study of migraine characteristics in joint hypermobility syndrome a.k.a. Ehlers-Danlos syndrome, hypermobility type","volume":"36","author":"Puledda","year":"2015","journal-title":"Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol"},{"key":"S109285292100064X_r58","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-014-0458-8"},{"key":"S109285292100064X_r43","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2676"},{"key":"S109285292100064X_r47","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00162"},{"key":"S109285292100064X_r98","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-678"},{"key":"S109285292100064X_r14","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-26"},{"key":"S109285292100064X_r70","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003554"},{"key":"S109285292100064X_r94","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0902-y"},{"key":"S109285292100064X_r118","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.9410"},{"key":"S109285292100064X_r5","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000252808.97649.21"},{"key":"S109285292100064X_r55","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419867280"},{"key":"S109285292100064X_r37","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24222"},{"key":"S109285292100064X_r48","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000687"},{"key":"S109285292100064X_r112","doi-asserted-by":"publisher","DOI":"10.1111\/head.13661"},{"key":"S109285292100064X_r78","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2009.00103.x"},{"key":"S109285292100064X_r63","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000091"},{"key":"S109285292100064X_r12","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900009226"},{"key":"S109285292100064X_r20","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283532ca3"},{"key":"S109285292100064X_r113","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0974-3"},{"key":"S109285292100064X_r106","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181ab2c20"},{"key":"S109285292100064X_r3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30322-3"},{"key":"S109285292100064X_r100","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0756-8"},{"key":"S109285292100064X_r59","first-page":"1","article-title":"Cortico-cortical connections of primary sensory areas and associated symptoms in migraine","volume":"3","author":"Hodkinson","year":"2017","journal-title":"eNeuro."},{"key":"S109285292100064X_r87","doi-asserted-by":"publisher","DOI":"10.1111\/head.13914"},{"key":"S109285292100064X_r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.01.029"},{"key":"S109285292100064X_r60","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000337"},{"key":"S109285292100064X_r57","unstructured":"57. Hartford, J , Graham, DR , Leyton-Brown, K , Ravanbakhsh, S. Deep models of interactions across sets. ArXiv180302879 Cs Stat. Published online June 8, 2018. http:\/\/arxiv.org\/abs\/1803.02879. Accessed July 7, 2020."},{"key":"S109285292100064X_r102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01486.x"},{"key":"S109285292100064X_r2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.8.813"},{"key":"S109285292100064X_r72","doi-asserted-by":"publisher","DOI":"10.1111\/head.13622"},{"key":"S109285292100064X_r54","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00140"},{"key":"S109285292100064X_r32","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14390"},{"key":"S109285292100064X_r84","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0988-x"},{"key":"S109285292100064X_r93","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00468.x"},{"key":"S109285292100064X_r92","doi-asserted-by":"publisher","DOI":"10.1111\/head.12953"},{"key":"S109285292100064X_r73","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4616417"},{"key":"S109285292100064X_r108","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i36.8149"},{"key":"S109285292100064X_r42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.04.016"},{"key":"S109285292100064X_r109","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008589"},{"key":"S109285292100064X_r67","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0789-z"},{"key":"S109285292100064X_r90","doi-asserted-by":"publisher","DOI":"10.1111\/head.12296"},{"key":"S109285292100064X_r69","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.03.008"},{"key":"S109285292100064X_r9","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-012-0482-1"},{"key":"S109285292100064X_r46","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415618614"},{"key":"S109285292100064X_r64","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01197-0"},{"key":"S109285292100064X_r52","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23705"},{"key":"S109285292100064X_r83","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00069"},{"key":"S109285292100064X_r50","first-page":"1","article-title":"Differentiation between migraine without aura and chronic tension-type headache based on HOS analysis of sEMG signals","author":"Biyouki","year":"2013","journal-title":"2013 21st Iranian Conference on Electrical Engineering (ICEE)"},{"key":"S109285292100064X_r7","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1066-0"},{"key":"S109285292100064X_r1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13275"},{"key":"S109285292100064X_r96","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.139"},{"key":"S109285292100064X_r13","doi-asserted-by":"publisher","DOI":"10.1101\/lm.025049.111"},{"key":"S109285292100064X_r95","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411430854"},{"key":"S109285292100064X_r65","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.02.006"},{"key":"S109285292100064X_r25","doi-asserted-by":"publisher","DOI":"10.1177\/2042098614522683"},{"key":"S109285292100064X_r79","volume-title":"Understanding Stress and Anxiety","author":"Spielberger","year":"1979"},{"key":"S109285292100064X_r86","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-010-0282-4"},{"key":"S109285292100064X_r110","doi-asserted-by":"publisher","DOI":"10.1080\/13814788.2019.1589806"},{"key":"S109285292100064X_r68","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417722570"},{"key":"S109285292100064X_r19","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000171"},{"key":"S109285292100064X_r33","doi-asserted-by":"publisher","DOI":"10.1080\/08964280309596169"},{"key":"S109285292100064X_r28","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0825-z"},{"key":"S109285292100064X_r66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2020.02.006"},{"key":"S109285292100064X_r104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01907.x"},{"key":"S109285292100064X_r31","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cbcd19"},{"key":"S109285292100064X_r77","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01705.x"},{"key":"S109285292100064X_r45","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-018-0150-2"},{"key":"S109285292100064X_r115","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0623-6"},{"key":"S109285292100064X_r23","doi-asserted-by":"publisher","DOI":"10.1097\/01.phm.0000223235.09931.c0"},{"key":"S109285292100064X_r44","doi-asserted-by":"publisher","DOI":"10.1038\/ng1016-1296c"},{"key":"S109285292100064X_r61","doi-asserted-by":"publisher","DOI":"10.1177\/0301006615599905"},{"key":"S109285292100064X_r22","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17072585"},{"key":"S109285292100064X_r16","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70126-6"},{"key":"S109285292100064X_r41","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01125-2"},{"key":"S109285292100064X_r40","first-page":"1","article-title":"Analysis of shared heritability in common disorders of the brain","volume":"360","author":"Anttila","year":"2018","journal-title":"Science"},{"key":"S109285292100064X_r105","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3282f6a629"},{"key":"S109285292100064X_r75","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412453952"},{"key":"S109285292100064X_r116","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2020.1715212"},{"key":"S109285292100064X_r39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01919.x"},{"key":"S109285292100064X_r38","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13111"},{"key":"S109285292100064X_r85","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2016.46"},{"key":"S109285292100064X_r71","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2003.03089.x"},{"key":"S109285292100064X_r34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-29821995.1505358.x"},{"key":"S109285292100064X_r4","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"S109285292100064X_r76","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"S109285292100064X_r56","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-9752(10)97063-2"},{"key":"S109285292100064X_r81","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-6494.1974.tb00690.x"},{"key":"S109285292100064X_r49","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.151"},{"key":"S109285292100064X_r89","doi-asserted-by":"publisher","DOI":"10.1177\/0333102409355601"},{"key":"S109285292100064X_r88","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00444.x"},{"key":"S109285292100064X_r6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.11.071"},{"key":"S109285292100064X_r99","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2005.05159.x"}],"container-title":["CNS Spectrums"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S109285292100064X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T10:28:25Z","timestamp":1666693705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S109285292100064X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,21]]},"references-count":118,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S109285292100064X"],"URL":"https:\/\/doi.org\/10.1017\/s109285292100064x","relation":{},"ISSN":["1092-8529","2165-6509"],"issn-type":[{"value":"1092-8529","type":"print"},{"value":"2165-6509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,21]]}}}