{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:55:51Z","timestamp":1784307351864,"version":"3.55.0"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"funder":[{"DOI":"10.13039\/100016503","name":"TLC Foundation for Body-Focused Repetitive Behaviors","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100016503","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S109285292100095X_sec1\"><jats:title>Background<\/jats:title><jats:p>Trichotillomania (TTM) and skin picking disorder (SPD) are common and often debilitating mental health conditions, grouped under the umbrella term of body-focused repetitive behaviors (BFRBs). Recent clinical subtyping found that there were three distinct subtypes of TTM and two of SPD. Whether these clinical subtypes map on to any unique neurobiological underpinnings, however, remains unknown.<\/jats:p><\/jats:sec><jats:sec id=\"S109285292100095X_sec2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Two hundred and fifty one adults [193 with a BFRB (85.5% [n\u00a0=\u00a0165] female) and 58 healthy controls (77.6% [n\u00a0=\u00a045] female)] were recruited from the community for a multicenter between-group comparison using structural neuroimaging. Differences in whole brain structure were compared across the subtypes of BFRBs, controlling for age, sex, scanning site, and intracranial volume.<\/jats:p><\/jats:sec><jats:sec id=\"S109285292100095X_sec3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>When the subtypes of TTM were compared, low awareness hair pullers demonstrated increased cortical volume in the lateral occipital lobe relative to controls and sensory sensitive pullers. In addition, impulsive\/perfectionist hair pullers showed relative decreased volume near the lingual gyrus of the inferior occipital\u2013parietal lobe compared with controls.<\/jats:p><\/jats:sec><jats:sec id=\"S109285292100095X_sec4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>These data indicate that the anatomical substrates of particular forms of BFRBs are dissociable, which may have implications for understanding clinical presentations and treatment response.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s109285292100095x","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T10:13:00Z","timestamp":1635934380000},"page":"98-103","source":"Crossref","is-referenced-by-count":12,"title":["Neurobiology of subtypes of trichotillomania and skin picking disorder"],"prefix":"10.1017","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7784-7021","authenticated-orcid":false,"given":"Jon E.","family":"Grant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A. 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