{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T21:43:29Z","timestamp":1774475009092,"version":"3.50.1"},"reference-count":46,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ministry of Science and Technology, R.O.C.","award":["MOST 107-2314-B-075-032-MY3-2"],"award-info":[{"award-number":["MOST 107-2314-B-075-032-MY3-2"]}]},{"name":"Ministry of Science and Technology, R.O.C.","award":["MOST 107-2314-B-075-032-MY3-2"],"award-info":[{"award-number":["MOST 107-2314-B-075-032-MY3-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1092852921000973_sec1\"><jats:title>Background<\/jats:title><jats:p>The concurrent incidence of autoimmune comorbidities in obsessive\u2013compulsive disorder (OCD) is known. However, the association between OCD and related autoimmune skin diseases (ASDs) has not been well studied.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852921000973_sec2\"><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the association between OCD and the risk of ASDs.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852921000973_sec3\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>To assess the risk of developing ASDs, we recruited 44\u00a0324 patients with OCD and 177\u00a0296 matched controls from the National Health Insurance Research Database in Taiwan. A Cox regression model was used for the analyses.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852921000973_sec4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>After adjusting for confounders, an increased risk of ASDs among the patients with OCD (adjusted hazard ratio [aHR]: 6.36; 95% confidence interval [CI]: 5.43-7.45) was found when compared to the controls. Statistically significant associations were found between OCD and seven individual ASDs, including psoriasis (aHR: 12.52; 95% CI: 8.78-17.85), lichen planus (aHR: 27.22; 95% CI: 13.09-56.60), alopecia areata (aHR: 13.69; 95% CI: 9.38-19.98), autoimmune bullous diseases (aHR: 4.30; 95% CI: 2.03-9.11), hidradenitis suppurativa (aHR: 29.95; 95% CI: 3.35-267.62), vitiligo (aHR: 9.35; 95% CI: 5.35-16.32), and lupus erythematosus (aHR: 2.10; 95% CI: 1.52-2.91).<\/jats:p><\/jats:sec><jats:sec id=\"S1092852921000973_sec5\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Patients with OCD had an increased risk of developing ASDs compared to matched controls. Further studies are required to clarify the underlying mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852921000973","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T10:37:20Z","timestamp":1644575840000},"page":"157-163","source":"Crossref","is-referenced-by-count":8,"title":["Obsessive\u2013compulsive disorder and the associated risk of autoimmune skin diseases: a nationwide population-based cohort 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