{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:36:11Z","timestamp":1763141771385,"version":"3.40.5"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1092852922000062_sec1\"><jats:title>Background<\/jats:title><jats:p>Behaviors typical of body-focused repetitive behavior disorders such as trichotillomania (TTM) and skin-picking disorder (SPD) are often associated with pleasure or relief, and with little or no physical pain, suggesting aberrant pain perception. Conclusive evidence about pain perception and correlates in these conditions is, however, lacking.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852922000062_sec2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A multisite international study examined pain perception and its physiological correlates in adults with TTM (n\u00a0=\u00a031), SPD (n\u00a0=\u00a024), and healthy controls (HCs; n\u00a0=\u00a026). The cold pressor test was administered, and measurements of pain perception and cardiovascular parameters were taken every 15\u00a0seconds. Pain perception, latency to pain tolerance, cardiovascular parameters and associations with illness severity, and comorbid depression, as well as interaction effects (group\u00a0\u00d7\u00a0time interval), were investigated across groups.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852922000062_sec3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>There were no group differences in pain ratings over time (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.8) or latency to pain tolerance (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.8). Illness severity was not associated with pain ratings (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). In terms of diastolic blood pressure (DBP), the main effect of group was statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), with post hoc analyses indicating higher mean DBP in TTM (95% confidence intervals [CI], 84.0-93.5) compared to SPD (95% CI, 73.5-84.2; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), and HCs (95% CI, 75.6-86.0; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). Pain perception did not differ between those with and those without depression (TTM: <jats:italic>P<\/jats:italic>\u00a0=\u00a0.2, SPD: <jats:italic>P<\/jats:italic>\u00a0=\u00a0.4).<\/jats:p><\/jats:sec><jats:sec id=\"S1092852922000062_sec4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>The study findings were mostly negative suggesting that <jats:italic>general<\/jats:italic> pain perception aberration is not involved in TTM and SPD. Other underlying drivers of hair-pulling and skin-picking behavior (eg, abnormal reward processing) should be investigated.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852922000062","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T08:27:18Z","timestamp":1647937638000},"page":"197-204","source":"Crossref","is-referenced-by-count":3,"title":["Pain perception and physiological correlates in body-focused repetitive behavior 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