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Outcomes of interest: Montgomery-\u00c5sberg Depression Rating Scale [MADRS], Functioning Assessment Short Test [FAST], Positive and Negative Syndrome Scale [PANSS]). LSMDs in change from baseline to end of study were reported in the overall intent-to-treat population and in patient subsets with specified levels of baseline cognitive symptoms or performance.<\/jats:p><\/jats:sec><jats:sec id=\"S109285292200013X_sec3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>In patients with bipolar depression and at least mild cognitive symptoms, LSMDs were statistically significant for cariprazine vs placebo on MADRS item 6 (3 studies; 1.5 mg=\u22120.5 [<jats:italic>P<\/jats:italic>&lt;.001]; 3 mg\/d=\u22120.2 [<jats:italic>P<\/jats:italic>&lt;.05]) and on the FAST Cognitive subscale (1 study; 1.5 mg\/d=\u22121.4; <jats:italic>P<\/jats:italic>=.0039). In patients with bipolar mania and at least mild cognitive symptoms, the LSMD in PANSS Cognitive subscale score was statistically significant for cariprazine vs placebo (3 studies; \u22122.1; <jats:italic>P<\/jats:italic>=.001). In patients with schizophrenia and high cognitive impairment, improvement in power of attention was observed for cariprazine 3 mg\/d vs placebo (<jats:italic>P<\/jats:italic>=.0080), but not for cariprazine 6 mg\/d; improvement in continuity of attention was observed for cariprazine 3 mg\/d (<jats:italic>P<\/jats:italic>=.0012) and 6 mg\/d (<jats:italic>P<\/jats:italic>=.0073).<\/jats:p><\/jats:sec><jats:sec id=\"S109285292200013X_sec4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>These post hoc analyses provide preliminary evidence of greater improvements for cariprazine vs placebo across cognitive measures in patients with bipolar I depression and mania, and schizophrenia, suggesting potential benefits for cariprazine in treating cognitive symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s109285292200013x","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T09:35:13Z","timestamp":1645608913000},"page":"319-330","source":"Crossref","is-referenced-by-count":28,"title":["The efficacy of cariprazine on cognition: a post hoc analysis from phase II\/III clinical trials in bipolar mania, bipolar depression, and schizophrenia"],"prefix":"10.1017","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4733-2523","authenticated-orcid":false,"given":"Roger S.","family":"McIntyre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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